Resistant Dextrin Solubilization of PQQ in Hard Water Beverages

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Solution Overview

Problem

Pyrroloquinoline quinone has low solubility in aqueous solvents and is prone to deposition, especially in hard water and acidic conditions, limiting its effectiveness in food and beverage applications.

Innovation Solution

The use of resistant dextrin as a solubilization enhancer increases the solubility of pyrroloquinoline quinone in aqueous solutions, including both soft and hard water, by forming a stable mixture with it.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If pyrroloquinoline quinone is added to aqueous solutions, then its physiological functions are provided, but its solubility is low and it is easily deposited

Engineering Contradiction:
Improvesolubility of pyrroloquinoline quinoneVSAvoiddeposition of pyrroloquinoline quinone
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

Resistant dextrin acts as an intermediary substance that interacts with pyrroloquinoline quinone to form a stable complex. This intermediary mechanism increases the apparent solubility of pyrroloquinoline quinone by preventing direct contact with water that would cause deposition, while maintaining the physiological activity of the quinone.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention creates a composite system combining resistant dextrin (a polysaccharide) and pyrroloquinoline quinone. This composite approach leverages the solubilizing properties of the dextrin to carry the quinone in aqueous solutions, forming a synergistic mixture that overcomes the low solubility issue while preserving biological functions.

Inventive Principle:
Principle #40Composite materials

2Quantity of substance

If hard water is used, then mineral content is increased, but solubility of pyrroloquinoline quinone is decreased

Engineering Contradiction:
Improvemineral content of waterVSAvoidsolubility of pyrroloquinoline quinone
Core Design Contradiction:
Quantity of substanceVSReliability

Solution Approach 1:

Resistant dextrin serves as a protective intermediary between the pyrroloquinoline quinone and the hard water minerals. The dextrin forms a complex with the quinone that resists interaction with calcium and magnesium ions, preventing precipitation and maintaining solubility even in hard water conditions.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Ease of operation

If acidic pH is used, then flavor enhancement is achieved, but pyrroloquinoline quinone is deposited

Engineering Contradiction:
Improveflavor enhancementVSAvoidsolubility of pyrroloquinoline quinone
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

Resistant dextrin acts as a protective intermediary that shields pyrroloquinoline quinone from acid-induced deposition. The polysaccharide complex maintains the quinone in solution even at acidic pH levels, allowing flavor enhancement through acidification without losing the quinone to precipitation.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Resistant dextrin enhances the solubility of pyrroloquinoline quinone, allowing for its stable presence in beverages over extended periods, irrespective of water hardness or pH, thereby maintaining its physiological benefits.

Implementation Method 1

the solubility of pyrroloquinoline quinone in an aqueous solution is increased in the presence of resistant dextrin

Methodology Applied
Scientific EffectSolubilization: Solvation

Data Source

PatentEP3701805B1Use of solubilization promoter for pyrroloquinoline quinone and method for promoting solubilization
Publication Date: 2025.11.26 MITSUBISHI GAS CHEM CO INC
  • EP3701805B1 patent drawing

AI summary

Provided is a solubilization enhancer for pyrroloquinoline quinone or a salt thereof in an aqueous solvent, comprising resistant dextrin as an active ingredient.