Resistant Starch Curcumin Carrier Bioavailability
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Solution Overview
Problem
Curcumin has poor bioavailability when administered orally, limiting its effectiveness for medicinal purposes due to inadequate absorption and fast metabolism, which existing formulations have struggled to overcome effectively.
Innovation Solution
A dietary fibre composition derived from plants, enriched with resistant starch and curcuminoids, is developed to enhance bioavailability by using a carrier and reducing metabolism, with the composition comprising 40% to 95% dietary fibre and 15% to 75% resistant starch, blended with plant extracts and nutrients for improved absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If curcumin is administered orally, then it provides medicinal benefits for conditions such as cancer, diabetes, and inflammatory disorders, but it has poor bioavailability due to inadequate absorption and fast metabolism
Solution Approach 1:
Resistant starch is used as an intermediary carrier substance to deliver curcuminoids through the gastrointestinal tract. The resistant starch forms a protective complex with curcumin, preventing its rapid metabolism and degradation, thereby enhancing its bioavailability and therapeutic effectiveness.
Solution Approach 2:
The invention creates a composite formulation combining curcuminoids with resistant starch and other dietary fibre components. This composite material leverages the protective and delivery properties of resistant starch to overcome the poor bioavailability of curcumin while maintaining its medicinal benefits.
2Reliability
If curcumin is administered orally, then it provides medicinal benefits, but absorption is inadequate
Solution Approach 1:
Resistant starch acts as a mediator that facilitates the absorption of curcuminoids. By forming a protective complex, it enables curcumin to survive the gastrointestinal environment and be effectively absorbed into the bloodstream, overcoming the inadequate absorption problem.
Solution Approach 2:
The invention changes the physical and chemical parameters of curcumin delivery by complexing it with resistant starch. This modification alters the solubility, stability, and absorption characteristics of curcumin, enabling improved bioavailability without changing the active curcuminoid molecules themselves.
Data Source
AI summary
The invention relates to a dietary fiber rich composition derived from plants parts, preferably from ginger, turmeric and Emblica. The composition has at least 45% dietary fiber and most of it is insoluble fibre. The insoluble fibre mostly comprises of resistant starch, the composition has at least 15% resistant starch. The invention also relates to a method of extracting and enrichment of fibre from plant parts. The method further includes solvent extraction, acid treatment and enzymatic treatment. The Starch in the composition either enriched and/or chemical modified. The composition has a place in novel food products, for food processing purposes, as functional food, dietary supplementation purposes and pharmaceutical preparations. Composition has clinically significant activity towards fat loss, blood glucose regulation, inhibiting inflammation and enhance bioavailability.