Resorbable Anchor Drug Delivery Device for Localized Tissue Treatment
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Solution Overview
Problem
Traditional drug delivery methods, such as oral administration and injections, face challenges in compliance and effectiveness, especially for chronic treatments, as they require active patient participation and can have systemic side effects, while transdermal patches and slow-release systems have limitations in drug penetration and matrix removal.
Innovation Solution
Development of biodegradable devices with a drug release portion and a resorbable anchor portion for localized drug delivery, allowing for controlled release of medications over time through a biologically compatible matrix, which can be implanted in tissues or organs, minimizing systemic effects and improving compliance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If traditional drug delivery methods (oral, injection) are used, then drug administration is simple, but patient compliance deteriorates and systemic side effects increase
Solution Approach 1:
The device segments the drug delivery system into distinct functional components: a drug release portion containing the therapeutic agent and a separate resorbable anchor portion for securing the device. This segmentation allows the drug delivery function to be simplified while the anchor portion ensures reliable retention and controlled release over time, improving both compliance and reducing systemic side effects through localized delivery.
2Duration of action of moving object
If transdermal patches are used, then drug delivery is continuous, but drug penetration capability deteriorates
Solution Approach 1:
The invention extracts the drug delivery function from the transdermal patch approach and places it directly at the target tissue site through implantation. By removing the constraint of skin barrier penetration and delivering the drug directly to the intended location, the system achieves continuous delivery without the penetration limitations of transdermal systems.
3Duration of action of moving object
If slow-release drug systems are used, then drug release is controlled, but matrix removal requires surgery
Solution Approach 1:
The anchor portion is designed to be resorbable, meaning it is discarded by the body's natural processes after serving its purpose of securing the device during drug release. This eliminates the need for surgical removal of the matrix, as the anchor portion degrades and is absorbed or excreted naturally after the drug has been delivered.
4Reliability
If biodegradable devices are used, then compliance improves, but device complexity increases
Solution Approach 1:
The device applies local quality by making only the anchor portion resorbable while keeping the drug release portion intact until drug delivery is complete. This localized application of biodegradability achieves improved compliance and eliminates surgical removal needs without requiring the entire device to be complex biodegradable structures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise and prolonged drug delivery directly to tissues or organs, reducing the need for frequent dosing and minimizing systemic side effects, enhancing therapeutic outcomes and patient compliance for chronic conditions like heart problems and infections.
Implementation Method 1
the binder is biologically degradable within a mammalian body at a first rate of degradation
Implementation Method 2
the at least one resorbable anchor portion is biologically degradable within the mammalian body at a second rate of degradation
Data Source
AI summary
Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.