Resorbable Bladder Endoprosthesis for Infection Reduction

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Solution Overview

Problem

Existing orthotopic artificial bladder endoprostheses are prone to bacterial infections due to their non-resorbable materials, which hinder the effectiveness of antibiotic treatments and can lead to complications even after patient rehabilitation.

Innovation Solution

An orthotopic artificial bladder endoprosthesis comprising two semispherical portions connected by resorbable sutures, made from biocompatible and resorbable PGA fibers for the fabric and PGA/PLA copolymer frames, allowing for tissue integration and antibiotic drug efficacy, with a textured surface to prevent adhesion and leaks.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If non-resorbable materials are used for the endoprosthesis casing, then the structural stability and shape retention are improved, but the risk of bacterial infections increases and antibiotic treatment effectiveness decreases

Engineering Contradiction:

Improvestructural stabilityVSAvoidbacterial infection risk

Core Design Contradiction:

Stability of the object's compositionVSObject-affected harmful factors

Solution Approach 1:

The patent changes the material parameter from non-resorbable to resorbable polymers (PGA, PLA, PCL), transforming the endoprosthesis from a permanent implant to a temporary support structure that degrades over time, thereby eliminating the long-term infection risk while maintaining initial structural stability

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The endoprosthesis is designed to be temporarily discarded as it resorbs into biocompatible byproducts, allowing the body to recover and form natural tissue in its place, thus eliminating the permanent foreign body that would otherwise serve as a bacterial reservoir

Inventive Principle:

Principle #34Discarding and recovering

2Object-affected harmful factors

If resorbable materials are used for the endoprosthesis, then the antibiotic treatment effectiveness is improved and infection risk is reduced, but the structural stability and load-bearing capacity may be compromised

Engineering Contradiction:

Improveantibiotic treatment effectivenessVSAvoidstructural strength

Core Design Contradiction:

Object-affected harmful factorsVSStrength

Solution Approach 1:

The patent employs composite material strategies by combining different resorbable polymers (PGA for strength, PLA for flexibility, PCL for slow degradation) and using layered or reinforced structures to achieve the required mechanical properties while maintaining biocompatibility and resorbability

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The endoprosthesis structure is designed to dynamically adapt its mechanical properties over time, providing high strength initially when needed for structural support, then gradually transitioning as the resorbable materials degrade and natural tissue takes over the load-bearing function

Inventive Principle:

Principle #15Dynamics

3Duration of action of stationary object

If the endoprosthesis is made as a permanent implant, then the long-term structural support is ensured, but complications can occur even after complete patient rehabilitation due to persistent foreign body presence

Engineering Contradiction:

Improvelong-term support durationVSAvoidcomplications from foreign body presence

Core Design Contradiction:

Duration of action of stationary objectVSObject-generated harmful factors

Solution Approach 1:

The patent changes the temporal parameter of the implant from permanent to temporary, with controlled degradation timelines that match the tissue regeneration process, allowing the endoprosthesis to provide support only when necessary and then safely disappear

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The endoprosthesis is designed as a temporary, disposable-like implant that fulfills its structural support function for a limited period and then resorbs into harmless byproducts, eliminating the need for removal surgery and preventing long-term complications associated with permanent foreign bodies

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The endoprosthesis reduces the risk of bacterial infections by enabling effective antibiotic penetration and complete resorption, ensuring no foreign body remains post-operation, facilitating tissue integration and proper bladder function.

Implementation Method 1

made from biocompatible and resorbable PGA fibers for the fabric and PGA/PLA copolymer frames, allowing for tissue integration and antibiotic drug efficacy

Methodology Applied

Scientific EffectBiodegradation: Decomposition (biological)

Implementation Method 2

The connection between the caps 4,5 is obtained by means of a resorbable suture 14

Methodology Applied

Scientific EffectHydrolysis: Hydrolysis

Data Source

PatentEP2908771B1Orthotopic artificial bladder endoprosthesis

Publication Date: 2016.11.30 SAMBUSSETI ANTONIO

Figure 1
Figure 2
Figure 3~4

AI summary

An orthotopic artificial bladder endoprosthesis comprises two portions (2, 3) connected to each other; each portion (2, 3) comprising a respective resorbable cap (4, 5) made of a PGA fiber fabric and a respective frame (6, 7), associated with said cap (4, 5), obtained by means of PGA/PLA copolymer; said portions (2, 3) being connected together in order to define a closed enclosure.