Resorbable Collagen Ceramic Membrane for Bone Regeneration
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Solution Overview
Problem
Current resorbable membranes for bone regeneration in the oral cavity face challenges such as high dehiscence rates, tissue irritation, and the need for additional surgeries due to inadequate mechanical stability and wound healing issues, particularly when using PLA or PLGA-based membranes.
Innovation Solution
A resorbable crosslinked form stable membrane composed of a composite layer of collagen material and inorganic ceramic particles, sandwiched between two layers of elastic pretensed collagen, providing mechanical stability against pressure, shear forces, and bending moments, while being biocompatible and resorbable to support bone formation and regeneration without excessive inflammation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of time
If PLA or PLGA-based resorbable membranes are used for bone regeneration, then the need for second surgery removal is eliminated, but tissue irritation and disturbed wound healing occur due to acid release during hydrolytic degradation
Solution Approach 1:
The patent converts the harmful acid release during degradation into a beneficial effect by using collagen as the base material, which degrades into harmless amino acids that actually promote wound healing. The crosslinking and ceramic reinforcement transform the material properties to achieve both resorbability and mechanical stability without tissue irritation.
Solution Approach 2:
The patent creates a composite material system combining collagen with inorganic ceramic particles (hydroxyapatite, tricalcium phosphate) and crosslinking agents. This composite structure provides mechanical stability equivalent to synthetic membranes while the collagen base ensures biocompatible degradation without harmful acid release.
2Strength
If Ti-meshes or Ti-reinforced PTFE membranes are used for mechanical stabilization, then form stability against oral forces is achieved, but high dehiscence rates and complications occur
Solution Approach 1:
The patent changes the material parameters by using crosslinked collagen with ceramic reinforcement, achieving tensile strength and form stability comparable to titanium-reinforced membranes. The crosslinking density and ceramic content are optimized to provide mechanical strength while maintaining biocompatibility and reducing dehiscence risk.
3Ease of manufacture
If non-reinforced PTFE membranes are used, then ease of manufacture and initial form stability are achieved, but they disappeared quickly after collagen membranes were introduced due to inferior biocompatibility
Solution Approach 1:
The patent creates a disposable resorbable membrane that serves its mechanical support function temporarily during bone regeneration, then degrades naturally. The collagen-based membrane is designed to be replaced by native tissue, eliminating the need for permanent implants or removal surgeries.
4Strength
If resorbable form stable membranes made from PLA or PLGA are used, then mechanical stability is improved, but wound healing is disturbed due to acid release during degradation
Solution Approach 1:
The patent transforms the degradation process from harmful to beneficial by using collagen, which breaks down into amino acids that are naturally metabolized and actually support tissue regeneration. The controlled crosslinking ensures mechanical stability is maintained throughout the degradation period.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The membrane achieves substantial mechanical stability, resisting forces and promoting bone regeneration with a lower risk of dehiscence and inflammation, as demonstrated by its performance in 3-point uniaxial bending tests and cell adhesion properties similar to Geistlich Bio-Gide®, indicating effective bone defect stabilization and healing.
Implementation Method 1
the collagen material having been submitted to a tensioning leading to a stretching of the collagen material in the linear region of the stress-strain curve
Implementation Method 2
resisting forces and promoting bone regeneration with a lower risk of dehiscence and inflammation
Data Source
AI summary
A resorbable crosslinked form stable membrane containing a composite layer of collagen material and inorganic ceramic particles containing 1.5 to 3.5 weight parts of inorganic ceramic for 1 weight part of collagen material, sandwiched between two layers of elastic pretensed collagen material, wherein the elastic pretensed collagen material is collagen material that has been stretched such as to be in the linear/elastic region of the stress-strain curve, the collagen material comprising 50-100% (w/w) collagen and 0-50% (w/w) elastin.