Resorbable Membrane with Embedded Collagen Particles
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Solution Overview
Problem
Existing resorbable covering membranes for medical wound treatment have limited hemostatic properties and slow absorption capacity, making them less effective for intraperitoneal use and prone to post-operative adhesions, which can lead to chronic pain and mechanical issues.
Innovation Solution
A resorbable covering membrane with collagen particles larger than 80 μm embedded in a polymer substrate layer, enhancing water absorption and bioavailability, promoting rapid hemostasis through increased swelling and thrombocyte adhesion, and designed for flexible adaptation to complex wound surfaces.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If nanoscale collagen particles (10-40 wt%) are used in the polymer substrate layer, then the covering membrane has good mechanical properties and permits undisturbed granulation tissue formation, but the hemostatic effect is limited and water absorption capacity is slow
Solution Approach 1:
The patent applies local quality by using two different collagen particle sizes in different regions: nanoscale collagen particles (1-10 μm) embedded in the polymer substrate layer provide mechanical strength and structural integrity, while larger collagen particles (80-500 μm) positioned on the wound-contact surface provide rapid hemostatic effect and water absorption. This spatial differentiation of particle sizes allows each region to optimize its function.
Solution Approach 2:
The patent creates a composite material structure combining polymer substrate (PLGA or similar) with a dual-size collagen particle system. The composite consists of: (1) polymer matrix with embedded nanoscale collagen for structural support, and (2) surface-layer larger collagen particles for rapid fluid absorption and hemostasis. This composite approach resolves the contradiction by integrating materials with complementary properties.
2Stability of the object's composition
If the covering membrane has slow adsorption and absorption capacity of fluids, then it maintains structural integrity, but it is suitable only to a limited extent for intraperitoneal use for preventing adhesions
Solution Approach 1:
The patent applies local quality by using two different collagen particle sizes in different regions: nanoscale collagen particles (1-10 μm) embedded in the polymer substrate layer provide mechanical strength and structural integrity, while larger collagen particles (80-500 μm) positioned on the wound-contact surface provide rapid hemostatic effect and water absorption. This spatial differentiation of particle sizes allows each region to optimize its function.
Solution Approach 2:
The patent creates a composite material structure combining polymer substrate (PLGA or similar) with a dual-size collagen particle system. The composite consists of: (1) polymer matrix with embedded nanoscale collagen for structural support, and (2) surface-layer larger collagen particles for rapid fluid absorption and hemostasis. This composite approach resolves the contradiction by integrating materials with complementary properties.
3Quantity of substance
If larger collagen particles (>80 μm) are used to improve hemostatic properties, then water binding capacity increases, but the particle size must be controlled to maintain proper membrane structure
Solution Approach 1:
The patent applies parameter changes by specifying a particular particle size range (80-500 μm, preferably 100-250 μm) for the larger collagen particles. This parameter optimization balances water absorption capacity with structural integrity: particles that are too small (<80 μm) absorb water too slowly, while particles that are too large (>500 μm) may compromise membrane structure and handling properties. The defined range represents an optimal compromise point.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The membrane achieves improved hemostatic and vascularization effects, accelerating wound healing and reducing the risk of adhesions, with a broader application spectrum including intraperitoneal use, by effectively absorbing excess fluids and promoting clotting.
Implementation Method 1
Due to the known swelling capacity of fibrillar collagen, i.e., collagen which is intact in its secondary or tertiary structure, the binding of water to the covering membrane can be accelerated and the water binding capacity of the covering membrane per unit area can be increased.
Implementation Method 2
the water absorption can also be promoted by the polymer material of the substrate layer itself. In the case of wound area application of the covering membrane, excess blood plasma and/or wound exudate can thus be removed more quickly and more effectively from the wound area.
Implementation Method 3
It is known that, in the case of wound contact of collagen, the binding of the von Willebrand factor (VWF) to the collagen and to the corresponding receptor of the thrombocyte membrane of thrombocytes and the adhesion of thrombocytes is promoted.
Implementation Method 4
The emptying of thrombocyte granules (degranulation) can be enhanced and the plasmatic blood clotting (secondary hemostasis) can be triggered or amplified.
Data Source
AI summary
A covering membrane for medical wound area treatment is disclosed for burns or for preventing adhesion. The covering membrane has a substrate layer including a polymer material as well as collagen particles which have a particle size I of more than 80 μm and are disposed in such a way as to be fixedly embedded in at least some portions of the polymer material of the substrate layer. The covering membrane further relates to a process for manufacturing such a covering membrane.