Resorbable Polymer Bone Graft with Controlled Calcium Release
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current bone grafts, including autografts, allografts, and synthetic materials, face limitations such as additional surgical trauma, limited availability, and suboptimal healing rates, with no ideal solution existing for skeletal defects, and they often fail to provide minerals at the right time for effective bone mineralization.
Innovation Solution
A bone graft with controlled release bone mineral ions, incorporating a resorbable polymer with calcium and/or phosphate ions, combined with demineralized bone matrix, which provides a controlled release of calcium and phosphate ions over a period of 1 week to 3 months to enhance bone mineralization and maturation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If autograft is used as bone graft material, then bone healing characteristics are improved, but additional surgical trauma and patient morbidity occur
Solution Approach 1:
The invention creates an artificial bone graft that copies the essential functional properties of autograft (osteoinductivity, osteoconductivity, osteogenesis) using allograft-derived demineralized bone matrix combined with growth factors and osteogenic cells, eliminating the need to harvest bone from the patient's own body while maintaining bone healing efficacy
Solution Approach 2:
The invention modifies the composition parameters of bone graft material by combining demineralized bone matrix with specific growth factors (BMPs, VEGF, FGF) and osteogenic cells in controlled ratios, transforming the material into a composite that achieves superior bone healing without requiring autologous bone harvest
2Reliability
If demineralized bone matrix is used, then bone remodeling is improved, but mineral availability at critical stages is insufficient
Solution Approach 1:
The invention pre-loading the bone graft with growth factors (BMPs, VEGF, FGF) and osteogenic cells before implantation, so that these biological agents are already present and activated at the graft site to stimulate rapid bone formation and mineralization, providing minerals at the right time without waiting for slow natural remodeling
Solution Approach 2:
The invention creates a composite bone graft material combining demineralized bone matrix with growth factors and osteogenic cells, where each component contributes specific functions: DBM provides osteoconductivity and structural framework, growth factors provide osteoinductivity and stimulate mineralization, and osteogenic cells provide osteogenesis and rapid bone formation
3Reliability
If bone graft is used to repair skeletal defects, then bone formation is achieved, but healing rate is insufficient
Solution Approach 1:
The invention pre-activates the bone graft by incorporating growth factors and osteogenic cells that are immediately upon implantation begin stimulating bone formation, eliminating the lag phase of conventional grafts and accelerating the healing rate from months to weeks
Solution Approach 2:
The growth factors incorporated in the bone graft create a positive feedback loop where initial bone formation releases more growth factors that further stimulate osteogenic cells and attract additional stem cells, creating a self-amplifying system that rapidly accelerates bone healing rate
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach accelerates bone formation and maturation by providing essential minerals at critical stages, improving healing rates and biomechanical integrity, while also serving as a radiographic marker for graft placement.
Implementation Method 1
the resorbable polymer of the bone graft is a protein or peptide including one or more of alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine and valine
Implementation Method 2
a resorbable polymer incorporated with a bone mineral ion donor to form a mineral-incorporated resorbable polymer
Implementation Method 3
demineralized bone matrix (DBM) mixed with the mineral-incorporated resorbable polymer
Implementation Method 4
the bone mineral ion donor of the bone graft is calcium peroxide, calcium ascorbate, calcium sulfate, calcium phosphate, calcium carbonate, calcium chloride, or mixtures thereof
Implementation Method 5
calcium peroxide, calcium ascorbate, calcium sulfate, calcium phosphate, calcium carbonate, calcium chloride
Data Source
AI summary
A bone graft for bone repair, the bone graft having controlled release bone mineral ions includes a resorbable polymer incorporated with a bone mineral ion donor to form a mineral-incorporated resorbable polymer, and demineralized bone matrix (DBM) mixed with the mineral-incorporated resorbable polymer.