Respiration Variability Sleep Staging for Timed OSA Stimulation

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Solution Overview

Problem

Current OSA stimulation systems fail to account for the wakefulness of the individual being treated, leading to inefficient battery life, incorrect stimulation application, and reduced patient compliance due to the lack of synchronization with the respiratory cycle and wakefulness detection.

Innovation Solution

A system that utilizes sensors to detect respiration effort and heart rate variability to determine wakefulness and sleep stages, adjusting stimulation parameters accordingly, including sensors like IMUs, microphones, and EKG sensors, and a controller to analyze respiration intervals and heart rate changes to deliver targeted nerve stimulation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of stationary object

If continuous stimulation is applied without wakefulness detection, then therapeutic coverage is maintained, but battery life is reduced and patient compliance decreases

Engineering Contradiction:
Improvebattery lifeVSAvoidtherapeutic coverage
Core Design Contradiction:
Duration of action of stationary objectVSReliability

Solution Approach 1:

The stimulation system dynamically adjusts its operation based on detected wakefulness states. Sensors continuously monitor physiological signals (respiration, heart rate, motion) and the controller modulates stimulation delivery accordingly - providing continuous therapy during sleep while reducing or pausing during wakeful periods, thus optimizing battery life without compromising therapeutic efficacy during appropriate states

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The system incorporates feedback loops where sensors detect physiological parameters and provide real-time information to the controller. The controller uses this feedback to determine wakefulness states and adjust stimulation parameters dynamically, creating a closed-loop system that adapts therapy delivery to the patient's actual state, thereby extending battery life while maintaining reliable therapeutic coverage when needed

Inventive Principle:
Principle #23Feedback

2Ease of operation

If stimulation is applied without wakefulness detection, then simple system operation is maintained, but incorrect stimulation application occurs

Engineering Contradiction:
Improvesystem operation simplicityVSAvoidwakefulness detection accuracy
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

The system employs multi-functional sensors that simultaneously monitor multiple physiological parameters (respiration rate, heart rate variability, motion patterns) to detect wakefulness. This universal sensing approach enables accurate wakefulness detection without requiring complex specialized sensors, maintaining ease of operation while achieving precise measurement of the patient's state through integrated analysis of multiple signals

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Measurement precision

If wakefulness detection sensors are added to OSA stimulation system, then stimulation accuracy is improved, but device complexity increases

Engineering Contradiction:
Improvestimulation timing accuracyVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent combines multiple sensing functions (respiration monitoring, heart rate detection, motion sensing) into an integrated wakefulness detection system. By merging these functions into a unified controller that processes multiple sensor inputs simultaneously, the system achieves high stimulation timing accuracy while minimizing the increase in device complexity through consolidated hardware and software architecture

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Improves power efficiency, accuracy, and patient compliance by ensuring stimulation is applied only when necessary, based on wakefulness and sleep stages, reducing incorrect applications and enhancing therapeutic outcomes.

Implementation Method 1

a first sensor configured to detect a signal indicative of respiration effort by the human subject when placed on or in proximity to one or more regions of a chest and/or head

Methodology Applied
Scientific EffectMechanical movement detection: Accelerometer

Implementation Method 2

EKG sensors

Methodology Applied
Scientific EffectElectrical signal detection: Electric Field

Data Source

PatentEP4444161B1Wakefulness and sleep stage detection using respiration effort variability
Publication Date: 2026.02.04 ALFRED E MANN FOUND FOR SCI RES
  • EP4444161B1 patent drawingFigure 1
  • EP4444161B1 patent drawingFigure 2
  • EP4444161B1 patent drawingFigure 3

AI summary

The present disclosure generally relates to systems and methods for monitoring and/or the sleep stage of an individual using one or more sensors, and methods of treating medical conditions related thereto (e.g., obstructive sleep apnea).