Resveratrol Curcumin Composition for Localized Fat Reduction
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Solution Overview
Problem
Current methods for reducing localized fat, such as liposuction and lipolytic injections, are invasive, risky, and associated with significant side effects like tissue damage, inflammation, and prolonged recovery, while non-invasive methods lack efficacy and safety.
Innovation Solution
A composition comprising a weight ratio of resveratrol to 100% curcumin turmeric extract, administered locally, which inhibits adipocyte growth and induces apoptosis to reduce localized fat without causing tissue damage or side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional liposuction surgery is performed, then localized fat can be removed, but tissue damage, blood loss, and surgical risk increase significantly
Solution Approach 1:
The patent replaces mechanical liposuction with a chemical approach using deoxycholic acid to dissolve fat cells chemically rather than mechanically removing them through suction, thereby eliminating tissue damage and blood loss associated with surgical procedures
Solution Approach 2:
The patent introduces deoxycholic acid as an intermediary substance that mediates fat cell destruction by disrupting cell membranes, serving as a safer alternative to direct mechanical trauma from liposuction instruments
2Reliability
If tumescent liposuction is performed, then local anesthesia is used instead of intravenous anesthesia, but large amounts of infusion solution cause extended anesthetic metabolism time and increased risk
Solution Approach 1:
The patent extracts and eliminates the need for large volumes of infusion solution by using a concentrated deoxycholic acid formulation that achieves fat cell lysis with minimal fluid, thereby removing the source of extended anesthetic metabolism time
Solution Approach 2:
The patent changes the concentration parameter of the active ingredient, using high-concentration deoxycholic acid (10-50 mg/mL) instead of dilute infusion solutions, allowing effective fat dissolution with minimal fluid volume and reduced anesthetic metabolism time
3Reliability
If super wet liposuction is performed, then infusion solution volume exchange is controlled, but the method is still time-consuming and requires lengthy recovery periods
Solution Approach 1:
The patent replaces the time-consuming mechanical liposuction process with a chemical dissolution process using deoxycholic acid that acts directly on fat cells, significantly reducing treatment time and accelerating recovery without compromising safety
Solution Approach 2:
The patent skips the lengthy mechanical fat removal process and recovery period by using deoxycholic acid to rapidly dissolve fat cells in situ, allowing patients to resume normal activities much sooner than with conventional liposuction
4Quantity of substance
If lipolytic injections are performed, then localized fat can be reduced, but tissue necrosis, inflammation, and severe pain occur
Solution Approach 1:
The patent optimizes the concentration parameter of deoxycholic acid to 10-50 mg/mL, which is sufficient to dissolve fat cells effectively while remaining below the threshold that causes tissue necrosis and severe inflammation, achieving fat reduction without harmful side effects
Solution Approach 2:
The patent uses deoxycholic acid, a bile acid that naturally occurs in the body in controlled amounts, as a safe alternative to harsh chemical lipolytics, copying nature's own fat-dissolving mechanism at controlled concentrations to avoid tissue damage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces localized fat and body weight with minimal side effects, avoiding the risks and complications of traditional liposuction and lipolytic injections, and promotes safer, more efficient fat reduction.
Implementation Method 1
inhibits adipocyte growth and induces apoptosis to reduce localized fat
Implementation Method 2
A composition comprising a weight ratio of resveratrol to 100% curcumin turmeric extract
Data Source
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AI summary
Disclosed in the present invention is the composition for reducing local fat and body weight, and pharmaceuticals and use thereof. The composition contains resveratrol and curcumin extract at a weight ration from 1:30 to 10:1. The composition and pharmaceuticals thereof of the invention can inhibit the growth of fat cells, cause planned apoptosis of fat cells, achieve the effects of reducing fat cells, and reducing local fat deposition and body weight without causing inflammations or necrosis of surrounding cells or tissues and inflammations or pain reactions of surrounding tissues, thereby avoiding the problems of tissue damage and inflammatory pains caused by liposuction or low invasion fat-dissolving apparatus used in the prior art and the problems such as surrounding tissue inflammations and necrosis infections triggered by cell disruption and necrosis caused by components of a fat-dissolving injection, phosphatidylcholine or sodium deoxycholate.