Resveratrol Pectin Granulation Flowability
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Solution Overview
Problem
Resveratrol crystalline powder exhibits poor flowability, making it difficult to use in applications like tablet formation due to its inability to be properly fluidized and granulated.
Innovation Solution
A composition of resveratrol coated or partially coated with pectin, where pectin acts as a binder to form granules with improved flowability, using methods like fluidized-bed granulation or spray-drying, with pectin content ranging from 0.1% to 15% by weight, and particle sizes optimized for effective granule formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If resveratrol crystalline powder is used directly, then the purity and potency are maintained, but the flowability is poor making it difficult to use in tablet formation
Solution Approach 1:
The patent combines resveratrol crystals with pectin to create a composite granulated material. The pectin acts as a binding agent that coats the resveratrol crystals, forming granules with improved flow properties while maintaining the active ingredient's integrity and potency for tablet formation.
Solution Approach 2:
The patent changes the physical parameters of resveratrol by granulating it with pectin under controlled conditions (specific particle size distribution, moisture content, and granule size parameters). This transforms the poor-flowing crystalline powder into granulated material with optimized physical properties for manufacturing.
2Productivity
If fluidized-bed granulation is attempted with resveratrol crystals, then granule formation is desired, but the very low flowability prevents proper fluidization
Solution Approach 1:
The patent applies a preliminary coating of pectin to the resveratrol crystals before attempting fluidized-bed granulation. This preliminary action improves the surface properties and flow characteristics of the crystals, enabling them to be properly fluidized and granulated in subsequent processing steps.
Solution Approach 2:
The pectin acts as an intermediary substance between the resveratrol crystals and the fluidization process. It coats the crystals and modifies their surface properties, allowing them to interact effectively with the fluidizing medium and enabling successful granulation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves enhanced flowability and granule formation, allowing for the successful production of tablets and other dosage forms, overcoming the limitations of existing methods that fail to improve resveratrol's fluidization and granulation.
Implementation Method 1
one or more resveratrol crystals are coated or partially coated with pectin. The coated or partially coated crystal or crystals are held (glued) together by pectin, which functions as a binder, to form a granule
Implementation Method 2
forming a fluidized bed of resveratrol with or without pectin, the fluidized bed being fluidized by air or an inert gas
Data Source
AI summary
The present invention relates to compositions, preferably in the form of a powder and/or granules, which contain resveratrol and pectin, and a process for the manufacture of such compositions.