Resveratrol Solubilization in Omega-3 Fatty Acid Formulations
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for preparing compositions containing resveratrol and omega-3 polyunsaturated fatty acids (n-3 PUFA) face challenges in solubilizing resveratrol in oil phases, as it is almost insoluble in most oil phases used, and existing methods are lengthy and expensive, such as microencapsulation or coating processes.
Innovation Solution
A solvent system comprising an ionic emulsifier, specifically deoiled phosphatidylcholine-enriched lecithin or Epikuron™ 200, and omega-3 polyunsaturated fatty acids (n-3 PUFA), which allows for the complete solubilization of resveratrol, forming a homogeneous composition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If microencapsulation or coating processes are used to solubilize resveratrol in oil phases, then solubilization is achieved, but the preparation process becomes lengthy and expensive
Solution Approach 1:
The patent introduces ionic emulsifiers (such as lecithin, polysorbates, or protein-based emulsifiers) as intermediary substances to facilitate the solubilization of resveratrol in oil phases. These emulsifiers act as mediators between the polar resveratrol and non-polar oil, forming stable microemulsions or mixed micelles that enable complete solubilization without requiring lengthy microencapsulation or coating processes. This intermediary approach achieves reliable solubilization while dramatically reducing preparation time and complexity.
2Reliability
If microencapsulation or coating processes are used to solubilize resveratrol in oil phases, then solubilization is achieved, but manufacturing cost increases
Solution Approach 1:
The patent employs ionic emulsifiers as cost-effective intermediary substances to achieve reliable solubilization of resveratrol in oil phases. These emulsifiers form stable mixed micelles or microemulsions that completely solubilize resveratrol without requiring expensive microencapsulation or coating equipment and processes. This approach maintains high solubilization effectiveness while significantly reducing manufacturing complexity and cost.
Solution Approach 2:
The patent utilizes parameter changes in the formulation system by adjusting the type and concentration of ionic emulsifiers to optimize solubilization. By changing the chemical parameters (emulsifier selection, ratio of components) rather than relying on complex physical processes like microencapsulation, the method achieves reliable solubilization at lower manufacturing costs with simpler processing requirements.
3Ease of manufacture
If resveratrol is dissolved in traditional oil phases, then the composition can be prepared, but resveratrol solubility is insufficient
Solution Approach 1:
The patent creates a composite solvent system combining traditional oil phases with ionic emulsifiers. This composite material approach forms mixed micelles or microemulsions where the oil provides the non-polar environment and the ionic emulsifier provides polar regions that can solubilize resveratrol. The synergistic combination of these components achieves complete resveratrol solubilization while maintaining ease of composition preparation.
Solution Approach 2:
The ionic emulsifier serves as an intermediary substance that bridges the polarity gap between resveratrol and traditional oil phases. By introducing this intermediary component, the system achieves high resveratrol solubility without compromising the ease of preparation, as the emulsifier naturally forms soluble complexes with resveratrol in the oil phase.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach achieves significant solubilization of resveratrol, with recovery rates of n-3 PUFA and resveratrol remaining high after storage at various temperatures, making it suitable for oral administration in preventing or treating cardiovascular diseases and other conditions.
Implementation Method 1
resveratrol is solubilized in a solvent system consisting of omega-3 polyunsaturated fatty acids (n-3 PUFA) or alkyl esters thereof, and a ionic emulsifier
Implementation Method 2
a solvent system consisting of: omega-3 polyunsaturated fatty acid or alkyl esters thereof; an ionic emulsifier
Data Source
AI summary
The present invention relates to homogeneous formulations comprising omega-3 polyunsaturated fatty acids (n-3 PUFA) and resveratrol for oral administration, in which the resveratrol is solubilized in a solvent system consisting of omega-3 polyunsaturated fatty acids (n-3 PUFA), or their alkyl esters, and a ionic emulsifier. The composition according to the present invention can be formulated as food or nutritional supplement or medicament in the prevention or treatment of cardiovascular diseases due to lipid metabolism disorders and increased platelets aggregation, as well as damages due to free radicals and/or viral diseases.