Reticular Oral Adhesive Patch Structure for Stable Removal
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Solution Overview
Problem
Conventional oral adhesive patches face issues with residue and delamination, leading to inferior efficacy and discomfort due to saliva dilution, and require complex manufacturing processes.
Innovation Solution
A patch design with a reticular structure that divides the drug layer into two sections, utilizing a backing layer and a reticular structure to prevent delamination and residue, allowing controlled release of active ingredients through a mesh-like structure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a water-soluble polymer is used in the drug layer to ensure stability of hydrogen peroxide, then adhesion to oral tissue is improved, but a significant amount of polymer remains on the tooth surface after use causing residue
Solution Approach 1:
The drug layer is divided into two distinct sections: a first water-soluble polymer layer in contact with the tooth surface that provides adhesion and allows controlled release, and a second water-insoluble polymer layer that provides stability to hydrogen peroxide. This segmentation allows each layer to perform its specific function without the drawbacks of the other - the water-soluble layer minimizes residue while the water-insoluble layer ensures stability.
2Strength
If a PE film backing layer is used to prevent rapid dilution by saliva and provide mechanical strength, then adhesion to teeth is improved and breakage is prevented, but delamination between the drug layer and backing layer occurs under certain conditions
Solution Approach 1:
The backing layer is constructed as a composite material combining PE film with a hydrophilic polymer layer. The PE film provides the necessary tensile strength and flexibility, while the hydrophilic polymer layer (such as hydroxypropyl cellulose or carboxymethyl cellulose) provides good adhesion to the drug layer and resistance to delamination under high temperature and long-term aging conditions.
3Ease of operation
If the patch is designed to be easily removable from the tooth surface, then user comfort is improved, but the patch may not remain stably attached during use
Solution Approach 1:
The patch employs different materials with different adhesion characteristics in different layers. The first water-soluble polymer layer in contact with the tooth provides moderate adhesion that allows easy removal, while the overall patch structure with the PE film backing and hydrophilic polymer intermediate layer ensures stable attachment during use. The local properties of each layer work together to achieve both stable adhesion during use and easy removal afterward.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch provides stable adhesion without residue, effective ingredient delivery, and easy removal, enhancing user comfort and efficacy.
Implementation Method 1
water-soluble polymers having good adhesion to teeth and/or oral tissue
Implementation Method 2
a reticular structure which divides the drug layer into multiple sections
Data Source
AI summary
The present disclosure provides a patch which is attached to a tooth or oral mucous membrane and releases an active ingredient to a portion attached, in which the patch comprises a drug layer having an adhesive surface attached to the tooth or oral mucous membrane and a backing layer laminated on the drug layer, and comprises at least one reticular structure inside the drug layer, and is divided into at least 2 drug layers at the boundary of or by the reticular structure. In particular, the patch have a restricted extensibility.