Retinal Disease Composition with Synergistic Antioxidants
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Solution Overview
Problem
There is a need for complementary treatment methods and compositions for retinal diseases, particularly ischemic and degenerative retinal conditions, as existing treatments do not adequately address the protection and functional recovery of the retina.
Innovation Solution
A composition comprising astaxanthin, piperine, boswellic acids, coenzyme Q10, curcuminoids, lutein, saffron, zeaxanthin, and optional additional antioxidants like resveratrol, bromelain, zinc, and copper, which promotes retinal protection and functional recovery by inhibiting TNFa expression and enhancing retinal function in post-ischemic stress conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing treatments are used for retinal diseases, then standard care is provided, but protection and functional recovery of the retina are not adequately addressed
Solution Approach 1:
The patent combines multiple natural compounds (astaxanthin, piperine, boswellic acids, coenzyme Q10, curcuminoids, lutein, saffron, zeaxanthin, resveratrol, bromelain, zinc, salicin) into a single compositional formulation to achieve synergistic protective effects on the retina that individual compounds cannot provide alone
Solution Approach 2:
The invention creates a composite therapeutic formulation integrating antioxidants, anti-inflammatory agents, and neuroprotective compounds from natural sources, forming a multi-component system that addresses multiple pathological mechanisms of retinal disease simultaneously
2Reliability
If a single compound is used for treatment, then the treatment is simple, but the efficacy in promoting retinal functional recovery is insufficient
Solution Approach 1:
Multiple natural compounds with complementary mechanisms of action are merged into one formulation to achieve synergistic effects that enhance retinal protection and functional recovery beyond what any single compound can accomplish
Solution Approach 2:
The compositional formulation serves multiple therapeutic functions simultaneously: antioxidant protection, anti-inflammatory action, neuroprotection, and metabolic support, making it a multi-functional treatment for retinal diseases
Data Source
Figure 1A~2
AI summary
The present invention relates to a composition comprising: astaxanthin, piperine, boswellic acids, coenzyme Q10, curcuminoids, lutein, zeaxanthin, saffron, copper and, optionally, resveratrol, bromelain, zinc, salicin and further antioxidants from natural sources. The present invention further relates to said composition for use in treating retinal diseases which are ischemic and/or degenerative in nature.