Retinal Image ML Prediction for Early Malady Progression

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Solution Overview

Problem

Current methods are inadequate in predicting the manifestation, development, and progression of retinal maladies, particularly diabetic retinopathy, due to the complexity of retinal changes and the interplay between retinal and systemic ailments.

Innovation Solution

A method and system utilizing specialized machine learning (ML) models trained on retinal images to predict the development or progression of retinal maladies by categorizing images into distinct types based on the presence or absence of maladies and their severity levels, employing multiple training phases with varying image orders to enhance prediction accuracy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional retinal imaging and classification methods are used, then the system is simple to operate, but the prediction accuracy of retinal malady manifestation and progression is insufficient

Engineering Contradiction:
Improveprediction accuracyVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The retinal image analysis is segmented into multiple specialized ML models, each trained on uniquely ordered subsets of retinal images to predict specific aspects of malady manifestation and progression. This segmentation allows the system to achieve high prediction accuracy through specialized analysis while managing complexity by dividing the overall task into manageable components.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The ML models are pre-trained on large datasets of uniquely ordered retinal images before deployment. This preliminary training action enables the models to learn complex patterns and relationships in retinal imagery, achieving high prediction accuracy when applied to new cases without requiring complex real-time processing.

Inventive Principle:
Principle #10Preliminary action

2Reliability

If multiple specialized ML models are trained on uniquely ordered retinal images, then the prediction capability improves, but the training complexity and computational resources increase

Engineering Contradiction:
Improveprediction reliabilityVSAvoidmodel training complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The training process is segmented into multiple phases, with each specialized ML model trained on uniquely ordered subsets of retinal images. This segmentation improves prediction reliability by allowing each model to specialize in specific patterns while managing training complexity through distributed, independent training processes.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The training methodology employs parameter changes by using uniquely ordered arrangements of retinal images for each model's training dataset. This approach enhances prediction reliability by exposing models to varied data presentations, while the systematic parameter variation follows manageable patterns that control training complexity.

Inventive Principle:
Principle #35Parameter changes

3Measurement precision

If retinal images are analyzed in detail to predict malady progression, then the measurement precision improves, but the time required for analysis increases

Engineering Contradiction:
Improvedetection precisionVSAvoidanalysis time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The ML models perform preliminary analysis by detecting early signs of retinal malady manifestation and progression through patterns learned during training. This preliminary detection capability achieves high measurement precision by identifying subtle indicators early, while reducing analysis time by avoiding the need for exhaustive manual examination of all image features.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentUS12493958B2Method and system for predicting manifestation or progression of a retinal malady and method for training machine learning (ML) models for the same
Publication Date: 2025.12.09 AEYE HEALTH INC
  • US12493958B2 patent drawing
  • US12493958B2 patent drawing
  • US12493958B2 patent drawing

AI summary

A method for making a prediction regarding a malady in a retina of a subject, the method including: (a) receiving at least one retinal image of the retina; (b) calculating a prediction about the retina based on the at least one retinal image of the retina using at least one specialized machine learning (ML) model, the prediction pertaining to whether the malady will develop or manifest or progress in the retina within a time-period.