Semifluorinated Alkane Retinal Tamponade for Visual Acuity

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current tamponade agents for treating retinal detachment, such as silicone oils, cause visual acuity issues due to mismatched refractive indices and emulsification, leading to the need for corrective lenses and decreased vision during treatment.

Innovation Solution

A composition comprising a mixture of semifluorinated alkanes with a refractive index of 1.310 to 1.365, closely matching the natural vitreous body's refractive index, to minimize emulsification and maintain visual acuity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If silicone oils are used as tamponade agents, then the retinal detachment can be treated effectively, but visual acuity deteriorates due to refractive index mismatch

Engineering Contradiction:

Improveeffectiveness of retinal detachment treatmentVSAvoidvisual acuity deterioration

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the refractive index parameter of the tamponade agent by using semifluorinated alkanes (refractive index 1.310-1.365) instead of conventional silicone oils (refractive index ~1.400), thereby matching the refractive index of the natural vitreous body and eliminating visual acuity deterioration while maintaining treatment effectiveness

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs composite material design by creating a mixture of semifluorinated alkanes with specific refractive indices to achieve a balanced composition that provides both effective tamponade function and optical compatibility with the eye's natural structures

Inventive Principle:

Principle #40Composite materials

2Reliability

If silicone oils are used as tamponade agents, then the retinal detachment can be treated, but emulsification occurs leading to further visual complications

Engineering Contradiction:

Improveeffectiveness of retinal detachment treatmentVSAvoidemulsification resistance

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent changes the chemical composition parameter by replacing silicone oil with semifluorinated alkanes, which have different surface tension and chemical properties that prevent emulsification with aqueous media, thereby maintaining compositional stability and preventing visual complications

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs a tamponade agent that is biocompatible and does not require long-term retention in the eye, allowing for temporary use during the critical healing period without causing persistent emulsification issues

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition reduces the need for visual acuity correction and prevents emulsification, providing a more user-friendly treatment for retinal detachment by matching the eye's refractive index.

Implementation Method 1

the refractive index of the composition being from about 1.310 to about 1.365

Methodology Applied

Scientific EffectRefraction: Refraction

Data Source

PatentUS20250345287A1Composition comprising a mixture of at least one oil and one or more semifluorinated alkanes, a use of the composition for treating a disease as well as a method of producing the composition and corresponding kits

Publication Date: 2025.11.13 FLUORON

AI summary

The present invention inter alia relates to a composition comprising a mixture of at least one oil and one or more semifluorinated alkanes, the refractive index of the composition being from about 1.310 to about 1.365, and to a use of said composition for treating a disease, wherein the disease optionally comprises treating a detached retina. The invention also relates to a kit of parts comprising the composition, and to a method of producing the composition.