Retinaldehyde Composition Stabilizing Vitamin A Against UV Depletion

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Solution Overview

Problem

Current topical retinoid applications for skin aging and UV-induced damage are limited by irritation and inefficiency in maintaining vitamin A levels, as retinoids are sensitive to UV radiation, leading to depletion and subsequent skin aging and potential carcinogenesis.

Innovation Solution

A topical composition combining retinaldehyde, glycylglycine oleamide, and delta-tocopheryl-glucopyranoside, which synergistically enhances vitamin A storage and bioavailability, providing a broad spectrum of action against photo-induced skin aging by stabilizing retinoids and reducing irritation through slow release of delta-tocopherol.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If topical retinoids are applied to treat skin aging and UV-induced damage, then vitamin A levels should increase, but retinoids are depleted by UV radiation leading to inefficiency and potential carcinogenesis

Engineering Contradiction:

Improvevitamin A levelsVSAvoidmaintainment of vitamin A levels

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The composition applies retinoids in the evening before UV exposure, and uses glycylglycine oleamide to maintain vitamin A levels throughout the night and into the next day, proactively preventing depletion rather than reacting to it

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

Glycylglycine oleamide acts as an intermediary substance that binds to retinoids and protects them from UV-induced depletion, allowing vitamin A to be maintained in the skin without direct exposure to degrading UV radiation

Inventive Principle:

Principle #24Intermediary (Mediator)

2Strength

If topical retinoids are applied to combat skin aging, then skin elasticity and firmness should improve, but UV-induced depletion reduces effectiveness and may cause carcinogenesis

Engineering Contradiction:

Improveskin elasticity and firmnessVSAvoidUV-induced depletion and carcinogenesis risk

Core Design Contradiction:

StrengthVSObject-affected harmful factors

Solution Approach 1:

The composition is applied in the evening before UV exposure, allowing retinoids to work on skin elasticity and firmness during nighttime when UV damage cannot interfere, while glycylglycine oleamide maintains vitamin A levels through the next day

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The composition acknowledges that UV radiation depletes retinoids, so it applies retinoids when UV exposure is minimal (evening/night) and uses glycylglycine oleamide to compensate for expected depletion, turning the harmful UV effect into a manageable parameter

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Quantity of substance

If retinaldehyde and glycylglycine oleamide are combined to enhance vitamin A storage, then vitamin A bioavailability should increase, but the composition complexity increases

Engineering Contradiction:

Improvevitamin A bioavailabilityVSAvoidcomposition structure

Core Design Contradiction:

Quantity of substanceVSDevice complexity

Solution Approach 1:

The patent combines retinaldehyde (a vitamin A derivative) with glycylglycine oleamide (a peptide derivative) in a single topical composition, allowing both substances to work synergistically to enhance and maintain vitamin A levels in the skin

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

Glycylglycine oleamide serves multiple functions: it binds to retinaldehyde to enhance vitamin A storage, maintains vitamin A levels throughout the day, and potentially provides additional skin benefits, reducing the need for multiple separate products

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentUS10213375B2Cosmetic or dermatological compositions combining cosmetiques retinaldehyde and glycylglycine oleamide and the cosmetic or dermatological uses thereof

Publication Date: 2019.02.26 PIERRE FABRE DERMO COSMETIQUE SA

AI summary

The invention concerns topical compositions based on retinaldehyde, glycylglycine oleamide and, if necessary, delta-tocopheryl-glucopyranoside, and their use in cosmetology and dermatology to combat skin ageing and more particularly light-induced skin ageing.