Retinol Formulation Stability via Mixed Tocopherol
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Solution Overview
Problem
Existing retinol formulations for personal care products face challenges in achieving high retinol concentration while maintaining stability and avoiding the use of banned antioxidants like BHT and BHA.
Innovation Solution
A formulation comprising 40-75 weight-% retinol, 20-55 weight-% of a specific solvent, and 0.1-5 weight-% mixed tocopherol, with a defined cis/trans isomer ratio of retinol, is used to create a stable and high-concentration retinol solution without the need for banned antioxidants.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If high amount of retinol is used in the formulation, then the concentration of retinol in the end market product can be kept high, but the stability of retinol during storage deteriorates
Solution Approach 1:
Mixed tocopherol acts as an intermediary substance that protects retinol from oxidation and degradation. The formulation uses 0.1-5 wt-% mixed tocopherol as an antioxidant mediator that stabilizes high concentrations of retinol (40-75 wt-%) during storage, allowing the retinol to maintain its efficacy without requiring banned antioxidants like BHT or BHA.
Solution Approach 2:
The invention changes the chemical composition parameters by selecting specific solvent ratios and antioxidant concentrations that optimize both retinol stability and concentration. By adjusting the formulation parameters within specified ranges (40-75 wt-% retinol, 20-55 wt-% solvent, 0.1-5 wt-% mixed tocopherol), the formulation achieves enhanced stability while maintaining high retinol content.
2Stability of the object's composition
If conventional antioxidants (BHT, BHA) are used to maintain stability, then the stability of the formulation is improved, but the formulation becomes non-compliant with regulatory standards in various countries
Solution Approach 1:
The invention extracts and removes the banned antioxidants (BHT and BHA) from the formulation while maintaining stability through alternative means. By eliminating these prohibited substances and replacing them with mixed tocopherol, the formulation achieves both regulatory compliance and stability requirements.
Solution Approach 2:
The invention replaces long-standing conventional antioxidants with a natural, renewable alternative (mixed tocopherol) that is effective but has different stability characteristics. This substitution allows the formulation to meet modern regulatory standards while maintaining protective functionality, effectively using a newer, compliant antioxidant system.
3Stability of the object's composition
If high concentration of solvents and other ingredients is used, then the formulation can be stable, but the concentration of retinol in the end market product must be kept low
Solution Approach 1:
The invention optimizes the parameter ranges of all formulation components to achieve the highest possible retinol concentration. By specifying precise ranges (40-75 wt-% retinol, 20-55 wt-% solvent, 0.1-5 wt-% mixed tocopherol), the formulation maximizes retinol content while maintaining stability, allowing end-market products to achieve higher effective concentrations of the active ingredient.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation achieves high retinol concentration with improved stability, allowing for a wide range of applications while adhering to regulatory standards by avoiding the use of prohibited antioxidants.
Implementation Method 1
a formulation (F) comprising 40-75 weight-% (wt-%), based on the total weight of the formulation, of retinol, and 20-55 wt-%, based on the total weight of the formulation, of at least one solvent
Implementation Method 2
0.1-5 wt-%, based on the total weight of the formulation, of mixed tocopherol... which has a defined mixture of cis and trans isomers, in the presence of mixed tocopherol
Data Source
AI summary
The present invention relates to a new formulation, which comprises a high amount of retinol, which has a defined mixture of cis and trans isomers, in a specific solvent and in the presence of mixed tocopherol.