Retinol Peptide Composition for Non-Therapeutic Epidermal Exfoliation

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Solution Overview

Problem

Existing retinol-based compositions for skin exfoliation often cause skin irritation, inflammation, and visible peeling, especially when used in high concentrations, limiting their effectiveness and user comfort.

Innovation Solution

A hydroalcoholic composition combining retinol with a peptide sequence corresponding to human TGF-beta 2 expressed in Nicotiana benthamiana plants, which reduces skin irritation and enhances exfoliation efficiency while maintaining retinol's stability and efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If high concentrations of retinol are used for intensive exfoliation, then exfoliation effectiveness is improved, but skin irritation and inflammation increase

Engineering Contradiction:

Improveexfoliation effectivenessVSAvoidskin irritation

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent introduces a peptide sequence corresponding to human TGF-beta 2 as an intermediary substance that mediates between retinol and skin cells. This peptide acts as a protective mediator that reduces the direct irritating contact between high-concentration retinol and skin receptors, thereby maintaining exfoliation effectiveness while reducing skin irritation and inflammation

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the chemical composition parameters by adding specific peptide sequences (TGF-beta 2) to the retinol formulation. This parameter change modifies the overall biological activity of the composition, allowing high retinol concentrations to be used without proportionally increasing irritation, as the peptide modifies the interaction parameters between retinol and skin cells

Inventive Principle:

Principle #35Parameter changes

2Speed

If high concentrations of retinol are used, then exfoliation speed is improved, but visible peeling and discomfort increase

Engineering Contradiction:

Improveexfoliation speedVSAvoidvisible peeling

Core Design Contradiction:

SpeedVSObject-generated harmful factors

Solution Approach 1:

The TGF-beta 2 peptide sequence serves as an intermediary that modulates the exfoliation process. It allows rapid exfoliation to occur while intercepting and reducing the formation of large visible flakes, transforming the peeling process into a less noticeable gradual shedding of smaller fragments

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent converts the potentially harmful effect of rapid exfoliation (which causes visible peeling and discomfort) into a beneficial controlled process. The peptide modifies the exfoliation mechanism so that while exfoliation remains fast, the harmful visible peeling is transformed into subtle, gradual skin renewal with smaller fragments

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Productivity

If retinol is applied to achieve exfoliation, then skin renewal is improved, but treatment time and recovery period increase

Engineering Contradiction:

Improveskin renewalVSAvoidrecovery period

Core Design Contradiction:

ProductivityVSLoss of time

Solution Approach 1:

The TGF-beta 2 peptide is incorporated into the formulation in advance to prepare the skin for retinol treatment. This preliminary action of having the protective peptide already present on the skin before and during retinol application prevents the formation of severe irritation and extended peeling, thereby reducing the required recovery period while maintaining skin renewal effectiveness

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition achieves a lower skin irritation potential and a less painful exfoliation process, even at high retinol concentrations, with exfoliation occurring in smaller, less visible fragments over a longer period, improving user comfort and aesthetic outcomes.

Implementation Method 1

A hydroalcoholic composition combining retinol with a peptide sequence corresponding to human TGF-beta 2 expressed in Nicotiana benthamiana plants, which reduces skin irritation

Methodology Applied

Scientific EffectAnti-inflammatory signaling:

Implementation Method 2

Vitamin A and its derivatives (including retinol) are lipophilic substances used in humans... Retinoids penetrate the calloused layer of the epidermis

Methodology Applied

Scientific EffectLipophilic diffusion: Diffusion

Implementation Method 3

this compound stimulates the proliferation of these cells

Methodology Applied

Scientific EffectCell proliferation:

Implementation Method 4

In the outer layers of the epidermis, retinol weakens the connections between epidermal cells and facilitates exfoliation

Methodology Applied

Scientific EffectCell adhesion weakening:

Data Source

PatentEP4288025B1Composition and method of non-therapeutic exfoliation of the epidermis

Publication Date: 2025.04.09 URGO RECH INNOVATION & DEVEMENT

Figure 1A~1B
Figure 1C~1D
Figure 2A~2C

AI summary

The subject of the invention is a hydroalcoholic-based composition comprising retinol, the composition comprises retinol in a concentration of 3 - 7 wt.%, and an ingredient having INCI name of Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76. The invention also relates to a method of non-therapeutic exfoliation of the outer layers of the epidermis.