Retractable Tissue Cassette for Automated Embedding
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Solution Overview
Problem
Conventional tissue sample processing methods require extensive manual handling, leading to increased risks of misidentification, cross-contamination, and sample loss, as well as prolonged processing times due to the need for human intervention during grossing and embedding steps.
Innovation Solution
A tissue cassette with a retractable retaining member and biasing element that automates the retention and orientation of tissue samples, reducing manual manipulation and incorporating a sealing mechanism to prevent fluid leakage, while allowing for automated processing and embedding in paraffin.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If manual handling of tissue samples is used during grossing and embedding steps, then flexibility and adaptability in sample processing are maintained, but the risk of misidentification, cross-contamination, and sample loss increases while processing time is prolonged
Solution Approach 1:
The device segments the tissue processing system into modular components: a base receptacle for holding the tissue sample, a detachable retaining member with engagement features, and an automated actuating mechanism. This segmentation allows the retaining member to be automatically positioned and secured, reducing manual handling while maintaining processing flexibility through modular assembly and detachment.
Solution Approach 2:
The patent introduces an intermediary automated actuating mechanism that mediates between the operator and the tissue sample. Instead of direct manual manipulation of the sample, the operator controls the actuating mechanism which then automatically positions, retains, and secures the retaining member, eliminating direct contact with the sample and reducing contamination risk.
2Productivity
If multiple manual manipulation steps are performed on tissue samples, then sample orientation and positioning can be adjusted, but processing time is significantly increased
Solution Approach 1:
The device incorporates preliminary action by pre-configuring the retaining member with specific engagement features and the base receptacle with corresponding retention features before the tissue sample is placed. The actuating mechanism is pre-positioned to automatically secure the retaining member, eliminating the need for time-consuming manual adjustment steps during the embedding process.
Solution Approach 2:
The retaining member and base receptacle are designed to self-align and self-secure through complementary geometric features. When the actuating mechanism activates, the components automatically engage and lock into place without requiring precise manual positioning, enabling the system to perform the retention function autonomously and rapidly.
3Reliability
If tissue samples are frequently handled and transferred between containers, then orientation for diagnostic viewing can be achieved, but the likelihood of sample loss or degradation increases
Solution Approach 1:
The patent merges the tissue sample holder, retaining mechanism, and orientation features into a single integrated cassette assembly. The retaining member with engagement features is permanently associated with the base receptacle, creating a unified device that maintains sample orientation and prevents loss during automated processing, eliminating the need for repeated transfers between separate containers.
Solution Approach 2:
The device incorporates dynamic elements through the actuating mechanism that can adjust the retention force and positioning of the retaining member. This dynamic capability allows the system to adapt to different tissue sample sizes and orientations while maintaining secure retention, ensuring sample integrity throughout the automated processing cycle without requiring manual intervention.
Data Source
Figure 1A~1B
Figure 2
Figure 3
AI summary
An apparatus for holding a tissue sample having a retaining member with a first tissue engaging surface and at least one biasing element. The first tissue engaging surface is moveably attached to the retaining member. The apparatus also has a base comprising a second tissue engaging surface which is configured to engage the retaining member to form an interior area with the first and second tissue engaging surfaces facing each other. The apparatus also has a retracting member connected to the retaining member which is configured to retract the first tissue engaging surface and compress the biasing element to form a gap between the tissue sample and one of the first tissue engaging surface and the second tissue engaging surface.