Reusable Solid Carrier for Nucleic Acid Preparation
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Solution Overview
Problem
Current methods for preparing nucleic acids are costly due to the degradation of solid carriers, which can only be used once, leading to increased expenses.
Innovation Solution
A compound with a specific structure is bonded to a substrate using a linking molecule, forming an amide or urea functional group, allowing the solid carrier to be reused during nucleic acid preparation without degrading.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a solid carrier is used for nucleic acid preparation, then the nucleic acid can be prepared efficiently, but the solid carrier degrades after one use leading to increased cost
Solution Approach 1:
The patent modifies the chemical structure of the solid carrier by introducing a specific compound with a divalent organic group (Z) that forms a stable bond with the substrate. This structural parameter change enables the solid carrier to resist degradation and be reused multiple times while maintaining its nucleic acid binding capability.
Solution Approach 2:
The patent creates a composite structure by combining the solid carrier substrate with a specific compound that has a divalent organic group. This composite material integrates the binding capability of the solid carrier with the stability of the compound-substrate linkage, preventing degradation and enabling reusability.
2Device complexity
If a solid carrier is designed for single use, then the structure can be simple, but the cost of preparation increases due to frequent replacement
Solution Approach 1:
The patent changes the chemical parameter of the solid carrier by introducing a specific compound with a divalent organic group that forms a stable linkage with the substrate. This modification enables reusability without significantly complicating the overall structure, balancing simplicity with cost-effectiveness through multiple uses.
3Loss of substance
If the solid carrier is made reusable, then the cost decreases, but the compound structure becomes more complex
Solution Approach 1:
The patent introduces a specific compound with a divalent organic group (Z) that can be configured in different forms (e.g., alkylene groups with varying carbon counts). This parameter change enables reusability while allowing flexibility in structure design to minimize complexity based on specific application requirements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The reusable solid carrier maintains effective binding sites and yields high-quality nucleic acid production, reducing preparation costs by enabling multiple uses.
Implementation Method 1
bonded to a substrate using a linking molecule, forming an amide or urea functional group
Data Source
AI summary
A compound, a solid carrier including the same and a method for preparing a nucleic acid are provided. The compound has a structure represented by Formula (1) as follows. In Formula (1), the definition of Y1, Y2, Z and * are the same as defined in the detailed description.