RFID-Integrated Organoids Via Self-Assembly for Tissue Integrity

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Solution Overview

Problem

Existing methods fail to incorporate RFID microchips into biological tissues without impairing their native structure and functions, limiting their application in tissue culture contexts.

Innovation Solution

Self-assembly mediated incorporation of ultracompact RFID sensors into organoids, allowing for wireless traceability and maintaining tissue functionality.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If RFID microchips are incorporated into biological tissue, then tracking capability is improved, but tissue structure and function are impaired

Engineering Contradiction:

Improvetracking capabilityVSAvoidtissue structure and function

Core Design Contradiction:

Measurement precisionVSReliability

Solution Approach 1:

The organoid system is segmented into multiple components: the biological organoid tissue and the integrated RFID microchip sensor. This segmentation allows the RFID chip to be incorporated without requiring modification of the entire tissue structure, enabling tracking capability while preserving the native organization and function of the organoid cells and extracellular matrix.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The RFID microchip sensor is nested within the organoid structure, with the chip positioned inside the organoid's extracellular matrix space. This nesting approach allows the tracking device to be embedded within the biological tissue without disrupting the overall organoid architecture, maintaining both tracking capability and tissue integrity.

Inventive Principle:

Principle #7Nested doll (Nesting)

2Measurement precision

If microchips are incorporated into organoids, then wireless traceability is improved, but device complexity increases

Engineering Contradiction:

Improvewireless traceabilityVSAvoidincorporation process

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The organoid system performs self-service by utilizing its own extracellular matrix and natural growth processes to incorporate and position the RFID microchip. The organoid's self-assembly and self-organization capabilities are harnessed to integrate the sensor without requiring complex external manipulation or surgical procedures, thereby reducing the overall device complexity of the incorporation process.

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

Traditional mechanical methods of chip implantation (surgery, injection, embedding) are replaced with a biochemical self-assembly process. The RFID chip is incorporated through the organoid's natural self-organization and extracellular matrix deposition, substituting complex mechanical manipulation with a simpler biochemical process that occurs during organoid culture.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The RFID-integrated organoids maintain native structure and function, enabling in vitro and in vivo tracking and phenotypic screening, with proof-of-principle experiments identifying genetic disorders like steatohepatitis.

Implementation Method 1

Self-assembly mediated incorporation of ultracompact RFID sensors into organoids

Methodology Applied

Scientific EffectSelf-assembly: Self-Assembly

Data Source

PatentUS12379372B2Digitalized human organoids and methods of using same

Publication Date: 2025.08.05 CHILDRENS HOSPITAL MEDICAL CENT DBA CINCINNATI CHILDRENS HOSPITAL MEDICAL CENT

AI summary

Disclosed are digitized organoids comprising a detectable sensor, such as, for example, a Radio frequency identification (RFID) based sensor. Further disclosed are methods for making the digitized organoids. The disclosed methods allow for self-assembly mediated incorporation of ultracompact RFID sensors into organoids. Methods of using the digitized organoids are also disclosed.