RFID Sensor Aptamer Recognition for Stable Analyte Detection
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Solution Overview
Problem
Conventional sensors face limitations in detecting chemical, biological, and physical species with high specificity and sensitivity, particularly in using natural receptors like antibodies and enzymes, which can be unstable and costly to produce.
Innovation Solution
A radio frequency based sensor incorporating an RFID tag with an analyte recognition element, such as aptamers, and a signal amplification entity, which generates detectable signals upon binding to target analytes, enhancing specificity and stability through conformational changes and immobilization functionalities.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If natural receptors like antibodies and enzymes are used for detection, then detection specificity is improved, but production cost and stability deteriorate
Solution Approach 1:
The patent uses aptamers as synthetic copies that mimic the binding function of natural antibodies and enzymes. These aptamers are nucleic acid sequences that can be selected through SELEX to specifically bind target analytes, providing detection specificity comparable to natural receptors while avoiding their stability and cost issues.
Solution Approach 2:
The patent employs aptamers which are chemically synthesized nucleic acid sequences that are inexpensive to produce compared to natural antibodies. These aptamers can be easily regenerated and replaced, making them a cost-effective alternative to expensive natural receptors that require complex purification and storage conditions.
2Measurement precision
If natural receptors like antibodies and enzymes are used for detection, then detection specificity is improved, but production cost deteriorates
Solution Approach 1:
The patent uses aptamers as synthetic copies that mimic the binding function of natural antibodies and enzymes. These aptamers are nucleic acid sequences that can be selected through SELEX to specifically bind target analytes, providing detection specificity comparable to natural receptors while avoiding their stability and cost issues.
Solution Approach 2:
The patent employs aptamers which are chemically synthesized nucleic acid sequences that are inexpensive to produce compared to natural antibodies. These aptamers can be easily regenerated and replaced, making them a cost-effective alternative to expensive natural receptors that require complex purification and storage conditions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sensor achieves improved detection capabilities with high specificity and affinity for target analytes, offering stability and cost-effectiveness, suitable for detecting proteins, enzymes, peptides, and other molecules, including early disease markers and environmental contaminants.
Implementation Method 1
an RFID tag having a substrate and generating an associated electromagnetic field
Data Source
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AI summary
A radio frequency based sensor is provided. The sensor comprises a radio frequency identification tag having a substrate, where the radio frequency identification tag generates an associated electromagnetic field. The sensor further includes an analyte recognition element in operative association with the substrate, where the analyte recognition element is capable of binding to a target analyte, and a signal amplification entity coupled to the analyte recognition element, where the signal amplification entity facilitates change in electromagnetic field in presence of the target analyte.