Rhamnose and Ascorbic Acid Synergy for Skin Aging
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Solution Overview
Problem
Current skincare products fail to effectively address the signs of skin aging, such as wrinkles and reduced skin firmness, by inadequately stimulating collagen synthesis and dermo-epidermal junction cohesion, leading to compromised skin integrity and increased vulnerability to mechanical stress.
Innovation Solution
A cosmetic composition combining rhamnose with ascorbic acid or its analogues, which stimulates keratinocyte proliferation, fibroblast activity, and the synthesis of collagens like procollagen I, collagen VI, VII, and XII, enhancing dermo-epidermal junction cohesion and lipid synthesis in the epidermis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If conventional skincare products are used, then basic skin maintenance is provided, but they fail to effectively stimulate collagen synthesis and improve dermo-epidermal junction cohesion
Solution Approach 1:
The patent combines rhamnose and ascorbic acid in a single cosmetic composition to achieve synergistic effects. Rhamnose stimulates keratinocyte proliferation and collagen synthesis, while ascorbic acid enhances collagen maturation and stability. This merging of two active compounds with complementary mechanisms resolves the contradiction by providing both enhanced collagen synthesis and improved skin integrity simultaneously.
Solution Approach 2:
The invention creates a composite cosmetic formulation containing rhamnose, ascorbic acid, and auxiliary ingredients that work together to address multiple aspects of skin aging. The composite nature of the composition allows for simultaneous stimulation of collagen production, improvement of dermo-epidermal junction cohesion, and enhancement of skin barrier function, thereby resolving the technical contradiction between collagen synthesis and skin integrity.
2Strength
If collagen synthesis is stimulated, then skin firmness and density improve, but the complexity of the composition increases
Solution Approach 1:
Rhamnose serves multiple functions in the composition: it stimulates keratinocyte proliferation, promotes collagen synthesis, and enhances skin barrier function. Ascorbic acid similarly performs multiple roles including collagen maturation, antioxidant protection, and anti-inflammatory effects. This multi-functionality reduces composition complexity by using compounds that address multiple targets simultaneously rather than requiring separate ingredients for each function.
3Stability of the object's composition
If keratinocyte proliferation is enhanced, then dermo-epidermal junction cohesion improves, but skin vulnerability to mechanical stress increases
Solution Approach 1:
The composition applies preliminary protective actions by incorporating ascorbic acid, which strengthens collagen fibers and improves skin elasticity before mechanical stress occurs. The antioxidant and anti-inflammatory properties of ascorbic acid pre-condition the skin to better withstand mechanical stress, counteracting the potential vulnerability created by enhanced keratinocyte proliferation and turnover.
Data Source
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AI summary
Use of cosmetic composition comprising association of at least one monosaccharide comprising mannose, and/or rhamnose, and at least one additional compound comprising ascorbic acid or its analogues and their mixture, to reduce and/or prevent signs of aging skin or its appendages, is claimed. Independent claims are included for: (1) a composition comprising the combination of the monosaccharide comprising mannose and/or rhamnose and the additional compound comprising ascorbic acid or its analogue, where the composition is devoid of a combination of xylitol and mannitol; and (2) a device comprising the association of the monosaccharide comprising mannose, and/or rhamnose and the additional compound comprising ascorbic acid or its analog, where the device is adapted to inject intraepidermal, intradermal and/or subcutaneously. ACTIVITY : Dermatological; Endocrine-Gen. MECHANISM OF ACTION : Procollagen I synthesis stimulator; Collagen VII synthesis stimulator.