Rice Koji Extract PPARα Activator for Lipid Metabolism
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Solution Overview
Problem
Current solutions lack effective and diverse options for activating PPARα to improve abnormal lipid metabolism and obesity, limiting the range of food-based interventions.
Innovation Solution
A PPARα activator is developed using an extract of rice koji containing 9-hydroxy-10,12-octadecadienoic acid (9-HODE: 10E, 12E) or its active fraction, which is incorporated into pharmaceutical compositions, food additives, supplements, and drinks to activate PPARα and suppress fat accumulation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If conventional PPARα activators from solanaceous plants, soybean fermented products, or acacia bark extracts are used, then obesity control effects are achieved, but the diversity of food-based options is limited
Solution Approach 1:
The invention identifies 9-HODE as a universal PPARα activator that can be derived from multiple diverse sources including koji, olive oil, and other foods. This multi-sourcing approach maintains the reliable PPARα activation effect while significantly expanding the diversity of food-based options for consumers.
Solution Approach 2:
The invention changes the source parameter of PPARα activators from traditional solanaceous plants and soybean products to include koji and other diverse food sources containing 9-HODE. This parameter change expands the versatility of food-based options while maintaining the therapeutic effectiveness through consistent 9-HODE content.
2Adaptability or versatility
If PPARα activators are extracted from multiple food sources, then the range of options for improving lipid metabolism is widened, but the complexity of identification and standardization increases
Solution Approach 1:
The invention extracts and identifies 9-HODE as the specific active component responsible for PPARα activation across different food sources. By focusing on this single identifiable marker compound, the complexity of standardization is reduced while maintaining the ability to offer diverse food-based options containing 9-HODE from various sources including koji.
3Reliability
If koji extract containing 9-HODE is used as a PPARα activator, then a novel and safe approach for managing obesity is provided, but the manufacturing and purification processes become more complex
Solution Approach 1:
The invention utilizes the natural presence of 9-HODE in koji byproducts or less valuable fractions, converting what would otherwise be waste or low-value material into a high-value PPARα activator source. This approach maintains safety and efficacy while reducing manufacturing complexity by leveraging existing 9-HODE content rather than requiring de novo synthesis.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of 9-HODE: 10E, 12E from rice koji effectively activates PPARα, promoting beta-oxidation of fatty acids and suppressing triglyceride accumulation, providing a novel and safe approach for managing obesity and metabolic syndrome.
Implementation Method 1
using a solvent to extract an extract that contains 9-hydroxy-10,12-octadecadienoic acid (9-HODE: 10E, 12E) from a koji with a solvent
Data Source
AI summary
The invention provides a novel PPARα activator, a pharmaceutical composition, a food or a drink, a food additive, a supplement and a method of producing these products. The PPARα activator includes an extract of a koji that contains 9-hydroxy-10,12-octadecadienoic acid (9-HODE: 10E, 12E) or an active fraction of the extract, as an active ingredient.