Resin-Modified Glass Ionomer Cement for Dental Remineralization
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Solution Overview
Problem
Current dental compositions struggle to effectively release calcium and fluoride ions simultaneously for remineralizing tooth structures while maintaining good adhesion properties and aesthetic expectations, with existing formulations often forming insoluble calcium fluoride, reducing calcium ion release.
Innovation Solution
A resin-modified glass ionomer cement (RM-GIC) dental composition is developed, comprising a calcium ions releasing component and a fluoride ions releasing component, formulated as a kit of parts with an acidic and non-acidic part, using a calcium ions releasing component with a capability of 400 to 700 mg/L and a fluoride ions releasing component with a capability of 1,500 to 3,500 mg/L, which are combined to provide sustained ion release and improved adhesion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If calcium and fluoride ions are released simultaneously from dental composition, then remineralization effectiveness is improved, but calcium fluoride precipitation occurs reducing ion release
Solution Approach 1:
The patent divides the ion release function into separate components: a calcium ion releasing component (basic calcium phosphate particles) and a fluoride ion releasing component (fluoride-containing glass particles). This segmentation prevents premature precipitation of calcium fluoride by spatially separating the calcium and fluoride sources, allowing each ion to be released independently and then combine on the tooth surface for effective remineralization.
Solution Approach 2:
The patent introduces an intermediary mechanism where the resin matrix and polyalkenoic acid act as mediators between the calcium and fluoride releasing components. These intermediaries control the release kinetics and prevent direct interaction between calcium and fluoride ions in the bulk material, thereby avoiding calcium fluoride precipitation while maintaining sustained ion release capability.
2Object-affected harmful factors
If fluoride ions are released to make tooth structure more acid resistant, then dental caries resistance is improved, but calcium ion release is reduced due to insoluble calcium fluoride formation
Solution Approach 1:
The patent segments the fluoride release function from calcium release by using distinct fluoride-containing glass particles separate from the basic calcium phosphate particles. This allows fluoride ions to be released for acid resistance without immediately reacting with calcium ions to form insoluble calcium fluoride, thereby maintaining calcium ion availability for remineralization.
Solution Approach 2:
The patent modifies the release parameters by controlling the solubility and dissolution rates of the separate calcium and fluoride components. By adjusting the chemical composition and particle characteristics of each component, the patent optimizes the release kinetics to ensure sustained ion delivery without premature precipitation, overcoming the limitation of conventional single-phase materials.
3Strength
If resin-modified glass ionomer cement is used for cementing dental restoration, then adhesion properties are improved, but aesthetic expectations may not be met
Solution Approach 1:
The patent employs a composite material system combining resin matrix, polyalkenoic acid, fluoride-containing glass particles, and basic calcium phosphate particles. This composite structure integrates the strong adhesion properties of glass ionomer cements with the aesthetic qualities of resin-based materials, achieving both functional and aesthetic requirements for dental restorations.
Solution Approach 2:
The patent creates a multi-functional dental composition that simultaneously provides: (1) adhesion to tooth structure through polyalkenoic acid reactions, (2) fluoride release for caries prevention, (3) calcium release for remineralization, and (4) aesthetic appearance through resin-based formulation. This universal material addresses multiple clinical requirements in a single product.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The dental composition achieves effective remineralization of tooth structures by sustained release of calcium and fluoride ions, maintaining adhesion properties and aesthetic expectations, with the calcium ions releasing component and fluoride ions releasing component working together to enhance the hardness and health of tooth surfaces.
Implementation Method 1
a calcium ions releasing component having a Ca-ions releasing capability
Implementation Method 2
if 2.5 g Ca-ions releasing component is steered in 50 ml de-ionized water
Implementation Method 3
a fluoride ions releasing component having a F-ions releasing capability
Implementation Method 4
if 2.5 g F-ions releasing component is steered in 50 ml de-ionized water
Implementation Method 5
dental composition comprising polymerizable components, initiator suitable for curing the polymerizable components
Data Source
AI summary
The invention relates to a dental composition comprising polymerizable components, an initiator suitable for curing the polymerizable components, a Ca-ions releasing component having a Ca-ions releasing capability of 400 to 700 mg/l (ppm) if 2.5 g Ca-ions releasing component is steered in 50 ml de-ionized water having a pH of 2 for 24 hours; a F-ions releasing component having a F-ions releasing capability of 1,500 to 3,500 mg/l (ppm) if 2.5 g F-ions releasing component is steered in 50 ml de-ionized water having a pH of 7 for 24 hours. The invention also relates to a kit of parts comprising such a dental composition according and the following items alone or in combination: dental adhesive, dental milling block, prefabricated dental crown. The dental composition is suitable for use in a process of remineralizing a defect tooth in the mouth of a mammal, the process comprising the step of fixing a dental restoration to the surface of the defect tooth with the dental composition.