Composite Enzymatic Disinfectant for RNA Virus Elimination
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Solution Overview
Problem
Current disinfectants are ineffective in completely eliminating RNA viruses like SARS-CoV-2 and influenza, which have high mutation rates and can survive on surfaces for extended periods, posing a significant threat to public health due to their airborne and surface transmission.
Innovation Solution
A combination of Ribonucleases (RNases), Proteinases, and detergents is used to target and break down the genomic RNA, lipid membrane, and envelope/nuclear proteins of RNA viruses, creating a broad-spectrum disinfectant effective across various concentrations, pH ranges, and temperatures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional disinfectants are used, then they can be applied broadly, but they are ineffective in completely eliminating RNA viruses
Solution Approach 1:
The patent combines three different types of agents (RNases, proteases, and detergents) into a composite disinfectant formulation. Each component targets different viral structures: RNases degrade genomic RNA, proteases cleave envelope/nuclear proteins, and detergents disrupt the lipid membrane. This multi-component composite approach achieves complete virus elimination while maintaining broad applicability against various RNA viruses including SARS-CoV-2 and influenza.
2Reliability
If synthetic chemical disinfectants are used, then they can provide strong disinfection, but they are harmful to the environment and human health
Solution Approach 1:
The patent employs biodegradable enzymatic components (RNases and proteases) that perform their disinfection function and then naturally degrade. These short-living biological agents eliminate viruses effectively but break down harmlessly afterward, unlike persistent synthetic chemicals. The detergents used are also selected to be environmentally compatible, creating a disinfectant that provides strong disinfection capability without long-term environmental or health harm.
3Object-affected harmful factors
If RNA viruses are not effectively eliminated, then transmission risk remains high, but current disinfectants cannot completely destroy the virus
Solution Approach 1:
The patent segments the viral destruction process into three independent but complementary actions: (1) RNases specifically target and degrade the genomic RNA, (2) proteases specifically target and cleave the envelope/nuclear proteins, and (3) detergents specifically target and disrupt the lipid membrane. By dividing the destruction task into these three segments, each acting on a different viral component, the formulation achieves complete virus elimination and eliminates transmission risk.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively degrades RNA viruses, providing a safe, environment-friendly, and convenient method for disinfecting surfaces, airways, and filters, ensuring the destruction of pathogens like SARS-CoV-2 and influenza, thereby reducing the risk of transmission.
Implementation Method 1
Ribonucleases (RNases) are a big family of hydrolytic enzymes that degrade RNA molecules. RNases catalyze the breakdown of RNA into smaller components.
Implementation Method 2
Proteases (also called peptidase or proteinase) are a group of enzymes that catalyzes proteolysis, the breakdown of proteins into smaller polypeptides or single amino acids. They do this by cleaving the peptide bonds within proteins by hydrolysis, a reaction where water breaks bonds.
Implementation Method 3
Detergents are amphiphilic molecules, containing both hydrophilic and hydrophobic regions. This amphiphilic property allows detergents to break protein-protein, protein-lipid and lipid-lipid associations, denature proteins and other macromolecules.
Data Source
AI summary
Pandemic COVID 19 causes global crisis in human health and economy. The pathogen of COVID 19, like the Influenzas causing common flus, belongs to a common type of virus called Ribonucleic Acid (RNA) virus. RNA viruses are composed of three structural components: genomic RNA, envelop and nuclear proteins, and bilayer lipid membrane. Targeting COVID 19 and all RNA viruses, the present invention describes an effective disinfectant system, which applies the combination of RNases, proteases, and detergents, at a broad range of concentration, pH, and temperature in the utilization, to eliminate the RNA viruses from any contaminated surfaces, airways, and filters. The disinfectant system provides an effective, convenient, environment friendly, and safe solution, for commercial and customer use, to disinfect RNA virus pathogens in concern.