Roasted Hop Extract and Xanthohumol Composition for Enhanced Bioavailability
Solution Overview
Problem
Current methods for enhancing the health-promoting effects of xanthohumol, a prenylflavonoid with diverse positive effects on human and animal health, are limited in achieving high bioavailability and stability, leading to suboptimal therapeutic outcomes for conditions like cancer, osteoporosis, metabolic syndrome, and cardiovascular diseases.
Innovation Solution
A composition combining a roasted extract with xanthohumol, where the roasted extract enhances the bioavailability and stability of xanthohumol, allowing for higher therapeutic efficacy by synergistically increasing its activity, potentially achieved through interactions that improve solubility and metabolic resistance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If xanthohumol is administered alone, then it has therapeutic effects, but its bioavailability and stability are limited
Solution Approach 1:
The patent combines xanthohumol with roasted extract components (proteins, polyphenols, carbohydrates) to form a composite composition. This composite structure protects xanthohumol from degradation, improves its solubility, and enhances its bioavailability while maintaining therapeutic efficacy.
Solution Approach 2:
The roasted extract acts as an intermediary substance that facilitates the absorption and stability of xanthohumol in the biological system. The complex matrix of roasted extract components serves as a protective medium that mediates between xanthohumol and the biological environment.
2Quantity of substance
If higher doses of xanthohumol are used to improve therapeutic efficacy, then treatment effectiveness increases, but stability and bioavailability challenges worsen
Solution Approach 1:
By formulating xanthohumol in a composite with roasted extract, the patent enables higher effective doses to be administered while maintaining stability. The roasted extract matrix protects the increased quantity of xanthohumol from degradation and improves its solubility and absorption.
3Device complexity
If xanthohumol is used without roasted extract, then the composition is simpler, but therapeutic effectiveness is reduced
Solution Approach 1:
The patent merges xanthohumol with roasted extract to create a synergistic composition. The combination of these components produces therapeutic effects greater than the sum of individual parts, enhancing effectiveness while maintaining a relatively simple two-component formulation.
Data Source
AI summary
The present invention primarily relates to specific uses of a composition containing a roasted extract and xanthohumol for health-promoting purposes. In particular, the invention relates to a composition, preferably pharmaceutical composition, comprising xanthohumol (XN), preferably in a therapeutically effective amount, for (i) use in the treatment and/or prevention of cancer, and/or (ii) use in the treatment and/or prevention of osteoporosis, and/or (iii) use in the treatment and/or prevention of metabolic syndrome, and/or (iv) use in the treatment and/or prevention of diabetes, and/or (v) use in the treatment and/or prevention of cardiovascular disease(s), and/or (vi) use as anti-oxidant, and/or (vii) use as detoxifying agent, and/or (viii) inhibiting metabolic activation of procarcinogenes, and/or (ix) use as anti-mutagenic and/or anti-genotoxic agent, and/or (x) use as anti-estrogenic and/or estrogenic agent, and/or (xi) inducing apoptosis, and/or (xii) use as anti-angiogenetic agent, and/or (xiii) use as anti-inflammatory agent, and/or (xiv) inhibiting NF-κΒ, and/or (xv) use in the treatment and/or prevention of infection(s), in particular, use as antimicrobial agent, wherein the composition comprises or consists of (a) a roasted extract and (b) XN, preferably a hop extract comprising XN, and/or wherein the composition is obtainable or obtained by mixing (a) a roasted extract and (b) XN or, preferably, a hop extract comprising XN.