Rocuronium Bromide Purification via Vacuum Microwave Drying
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Solution Overview
Problem
Current methods for purifying rocuronium bromide struggle to efficiently remove residual solvents, particularly diethyl ether and other high-boiling solvents, due to their strong bonding with the rocuronium molecule, leading to high impurity levels and safety hazards, and existing methods like vacuum drying and freeze drying are either inefficient or costly and energy-intensive.
Innovation Solution
The method involves using vacuum microwave drying or fluidized drying to remove residual solvents from crude rocuronium bromide, employing solvents like methanol, ethanol, or acetone to facilitate solvent removal while controlling temperature and vacuum levels to meet medicinal standards, thereby reducing impurity levels and energy consumption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional vacuum drying or freeze drying is used to remove residual solvents from crude rocuronium bromide, then the solvent removal efficiency is low, but the process is energy-intensive and time-consuming
Solution Approach 1:
The patent employs freeze-drying technology which utilizes phase transition of water from solid to vapor (sublimation) under vacuum conditions. The crude rocuronium bromide is first frozen, then dried under vacuum to remove residual solvents through sublimation, achieving both high solvent removal efficiency and energy savings compared to conventional heating methods
Solution Approach 2:
The patent replaces conventional thermal drying mechanisms with a freeze-drying system that uses vacuum and controlled temperature phases. Instead of applying continuous heat to evaporate solvents, the system uses freezing followed by vacuum sublimation, substituting mechanical/physical phase control for thermal mechanical evaporation
2Productivity
If high temperature is applied to remove solvents from solvates, then solvent removal is effective, but rocuronium bromide decomposes due to heat sensitivity
Solution Approach 1:
The patent uses freeze-drying which controls phase transitions (freezing then sublimation) to remove solvents at low temperatures. The process avoids high temperature application by utilizing the phase change from solid ice directly to vapor under vacuum, preventing thermal decomposition of heat-sensitive rocuronium bromide while effectively removing solvents
Solution Approach 2:
The patent changes the temperature parameter throughout the process - first lowering temperature to freeze the material, then maintaining low temperature during vacuum drying. This parameter control ensures solvent removal occurs without exposing the heat-sensitive rocuronium bromide to decomposition temperatures
3Productivity
If diethyl ether is used as anti-solvent for crystallization, then crystallization efficiency is high, but safety hazards increase due to flammability and explosivity
Solution Approach 1:
The patent replaces the hazardous diethyl ether anti-solvent with water, which is safe, non-flammable, and readily available. Although water requires different crystallization parameters, it achieves effective crystallization without the safety hazards of flammable solvents, making the process suitable for large-scale industrial production
Solution Approach 2:
The patent uses water as an inert, non-flammable medium for crystallization instead of diethyl ether. Water creates a safe processing environment that eliminates fire and explosion risks while still enabling effective crystallization of rocuronium bromide through controlled temperature and concentration parameters
4Manufacturing precision
If multiple drying steps are used to meet medicinal solvent standards, then purity increases, but processing time and complexity increase
Solution Approach 1:
The patent performs preliminary removal of bulk solvents during the crystallization step by using water as anti-solvent and controlling crystallization conditions. This preliminary action reduces the solvent load before freeze-drying, allowing the final medicinal-grade purity to be achieved more quickly and with fewer additional drying steps
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach effectively reduces residual solvent content to meet medicinal standards, minimizes impurities, and avoids the use of hazardous solvents like diethyl ether, making the process safer, more efficient, and cost-effective for large-scale industrial production.
Implementation Method 1
removing the residual solvent in the crude rocuronium bromide by vacuum microwave drying method or fluidized drying method
Implementation Method 2
vacuum microwave drying method
Implementation Method 3
fluidized drying method
Implementation Method 4
fluidized drying method
Data Source
AI summary
The present application provides a method for purifying crude rocuronium bromide. The method includes removing the residual solvent in crude rocuronium bromide by vacuum microwave drying or fluidized drying to meet medicinal requirements. High-quality rocuronium bromide can be obtained by the method of the present application. The method makes the large-scale industrial production of rocuronium bromide easy to realize, and can also avoid or reduce the use of diethyl ether which is a flammable and explosive solvent. In addition, the equipment used requires less expense and occupies less space.