Fertilized Roe Extract for Accelerated Skin Wound Healing
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Solution Overview
Problem
Current wound healing processes are hindered by prolonged inflammatory phases, increasing the risk of infection and delayed healing, particularly in dermal tissue remodeling, and there is a need for effective utilization of excess fertilized roe from aquaculture to enhance wound care.
Innovation Solution
A pharmaceutical composition utilizing low-temperature extracted fertilized roe extract from specific fish species, which exhibits antioxidant activity, inhibits melanin production, and promotes collagen synthesis, is applied topically or orally to accelerate wound healing and reduce infection risk.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the inflammatory period becomes longer, then the wound healing process can be more complete, but the chance of infection and delay of wound healing increases
Solution Approach 1:
The patent applies preliminary action by using fertilized roe extract that contains pre-formed growth factors and cytokines to accelerate the wound healing process from the early inflammatory stage. The extract promotes rapid proliferation of fibroblasts and epithelial cells, enabling the wound to progress through healing phases more quickly while maintaining completeness, thereby reducing the time window for infection risk.
2Loss of time
If the dermal tissue remodeling is accelerated, then the wound healing time is reduced, but the complexity of the healing process increases
Solution Approach 1:
The patent applies parameter changes by modifying the biochemical environment of the wound site through fertilized roe extract application. The extract contains high concentrations of growth factors (such as EGF, FGF, VEGF) and cytokines that alter cell proliferation rates, collagen synthesis, and angiogenesis parameters, thereby accelerating dermal remodeling without requiring complex external intervention or multiple treatment modalities.
3Loss of substance
If the fertilized roe is discarded due to market demand changes, then the resource waste is minimized, but the added value of aquaculture is reduced
Solution Approach 1:
The patent applies blessing in disguise by converting the previously wasted fertilized roe into a valuable pharmaceutical and cosmetic ingredient. The extract from fertilized roe, which was previously discarded due to market demand changes, is now utilized for wound healing applications, transforming a waste product into a beneficial substance that adds significant value to the aquaculture industry while addressing wound care needs.
4Reliability
If the fertilized roe extract concentration is increased, then the wound healing effect is enhanced, but the risk of skin irritation and toxicity increases
Solution Approach 1:
The patent applies parameter changes by optimizing the concentration parameters of the fertilized roe extract for wound healing applications. Through systematic evaluation, the patent identifies safe and effective concentration ranges that maximize healing efficacy while minimizing skin irritation and toxicity risks, allowing for tailored application protocols that balance therapeutic benefit with safety.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The fertilized roe extract significantly shortens the inflammatory phase, promotes dermal reconstruction, and accelerates skin wound healing, including severe injuries, by scavenging free radicals, inhibiting tyrosinase activity, and enhancing collagen synthesis, making it suitable for medical and cosmetic applications.
Implementation Method 1
The fertilized roe extract has antioxidant activity... The fertilized roe extract has the ability to scavenge 50% of free radicals
Implementation Method 2
inhibiting tyrosinase activity and facilitating collagen synthesis... inhibiting the activity of tyrosinase
Implementation Method 3
facilitating collagen synthesis... the fertilized roe extract... promotes collagen synthesis... enhancing collagen synthesis
Implementation Method 4
The fertilized roe extract is obtained by extracting a fertilized roe by using low-temperature water
Data Source
AI summary
A composition for use in wound healing and therefor is disclosed. The multiple components of fish fertilized roe are extracted. By virtue of its ability as an anti-oxidant to eliminate free radicals, inhibition of tyrosinase activity and facilitate the mass secretion of collagen from skin fibroblasts in order to promote skin whitening, anti-aging and wound healing. Accordingly, skin all-round repair is achieved, which is used as a cosmetic raw material and a wound dressing.