Roll-to-Roll Nanoparticle Formation via Nip Point Cavity Filling

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Current nanotechnology manufacturing processes face challenges in producing nanometer-scale products in volume due to limitations in batch processing, which fail to meet the yield required for mass production, necessitating a transition to robust and dynamic roll-to-roll processing.

Innovation Solution

A method involving applying a liquid polymer composition to a mold with nanoscale cavities, passing it through a nip point to fill the cavities, and hardening the composition to form nanoparticles that mimic the cavity shape, with subsequent harvesting and solvent-based particle release for collection.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If batch type processing is used with high precision machinery, then manufacturing precision is improved, but productivity deteriorates due to inability to meet mass production yield requirements

Engineering Contradiction:
Improvenanometer scale structure precisionVSAvoidmass production yield
Core Design Contradiction:
Manufacturing precisionVSProductivity

Solution Approach 1:

The patent implements continuous roll-to-roll processing where the substrate continuously passes through the nip point between rollers, enabling uninterrupted particle formation and deposition. This continuous operation replaces batch processing, dramatically increasing productivity while maintaining nanometer-scale precision through controlled roller geometry and material properties.

Inventive Principle:
Principle #20Continuity of useful action

Solution Approach 2:

The patent replaces complex high precision machinery with a simpler roller-based system that uses the inherent properties of the material (viscoelasticity, surface tension) and roller geometry to achieve precise nanometer-scale particle formation. The mechanical complexity is reduced while maintaining precision through material-roller interactions rather than complex positioning systems.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Productivity

If roll to roll processing is implemented, then productivity is improved for mass production, but manufacturing precision may deteriorate compared to batch processing

Engineering Contradiction:
Improvecontinuous production capabilityVSAvoidnanometer scale structure control
Core Design Contradiction:
ProductivityVSManufacturing precision

Solution Approach 1:

The patent controls particle formation by adjusting critical parameters including roller surface energy, roller temperature, substrate speed, and material composition. These parameter changes enable precise control of particle size and shape (nanometer scale) while maintaining continuous high-speed operation, resolving the contradiction between productivity and precision.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The material's own properties (viscoelasticity, surface tension, phase transition characteristics) are utilized to self-organize into precise nanometer-scale particles during the rolling process. The material essentially forms the desired structure itself through controlled phase separation and surface effects, reducing the need for complex external control mechanisms and maintaining precision at high speeds.

Inventive Principle:
Principle #25Self-service

3Manufacturing precision

If excess material is removed by blade from mold, then particle formation is achieved, but device complexity increases and productivity decreases

Engineering Contradiction:
Improveparticle size controlVSAvoidseparate removal mechanism
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent extracts the excess material removal function from the particle formation process itself. The nip point geometry and material properties cause excess material to be naturally excluded at the roller interface, while particles form within the cavities. This eliminates the need for separate blade removal mechanisms, reducing device complexity and increasing productivity.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent merges the particle formation and excess material removal functions into a single integrated process at the nip point. Both functions occur simultaneously as the substrate passes between rollers, eliminating the need for sequential operations and separate removal mechanisms, thereby simplifying the device and increasing throughput.

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables continuous production of nanoparticles with precise size and shape, overcoming batch processing limitations and enhancing scalability for mass production.

Implementation Method 1

hardening the substantially liquid composition in the cavities of the mold to form a particle within each cavity

Methodology Applied
Scientific EffectPhase change: Phase Change

Data Source

PatentEP2207670B1Method for producing particles and patterned films
Publication Date: 2019.05.22 LIQUIDIA TECHNOLOGIES INC
  • EP2207670B1 patent drawingFigure 1
  • EP2207670B1 patent drawingFigure 2
  • EP2207670B1 patent drawingFigure 3

AI summary

A mold having a fluoropolymer wherein the mold defines cavities having a shape and a cross-sectional dimension less than 100 micrometers, a roller, a surface in cooperation with the roller to form a nip point to receive the mold, wherein the nip point receives a liquid and accelerates entry of the liquid into the cavity Forming particles includes applying a liquid to a mold, wherein the mold comprises a fluoropolymer and defines a cavities each having a broadest crosssectional dimension of less than 100 micrometers, nipping the mold between a roller and a surface such that the liquid enters the cavities of the mold, and hardening the liquid in the cavities of the mold to form a particle within each cavity, wherein the particle has a size and shape that mimics the size and shape of th cavity of the mold