Ropinirole Patch with Sodium Carboxylate for Skin Permeability
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Solution Overview
Problem
Existing ropinirole-containing patches do not adequately address the issue of skin permeability, despite the use of absorption enhancers and desalting agents like sodium hydroxide.
Innovation Solution
Incorporating a specific sodium carboxylate, such as sodium pentanoate, disodium glutarate, or sodium hexanoate, into the adhesive agent layer of a patch comprising a backing layer and an adhesive agent layer to enhance skin permeability of ropinirole and its pharmaceutically acceptable salts.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If absorption enhancers and desalting agents like sodium hydroxide are used in ropinirole-containing patches, then skin permeability of ropinirole is improved, but cohesive force and adhesiveness of the adhesive agent layer deteriorate
Solution Approach 1:
The patent changes the chemical parameter of the adhesive agent by selecting specific polymers with particular functional groups (carboxyl, hydroxyl, or amine groups with specific content ranges). This parameter change allows the adhesive to maintain cohesive force while improving ropinirole skin permeability, resolving the contradiction between drug delivery effectiveness and adhesive integrity
Solution Approach 2:
The patent uses composite adhesive materials that combine polymer bases with specific functional groups and additional components. These composite materials provide both the necessary adhesive properties (cohesive force) and the drug release properties (skin permeability enhancement) simultaneously, resolving the contradiction between maintaining adhesive strength and improving drug permeation
2Reliability
If conventional adhesive agents are used in ropinirole-containing patches, then ease of manufacture is maintained, but skin permeability of ropinirole is insufficient
Solution Approach 1:
The patent modifies the adhesive agent parameters (polymer type, functional group content, molecular weight) to achieve both improved skin permeability and manufacturing feasibility. The specified ranges for carboxyl, hydroxyl, or amine group content (0.1-10 mmol/g) balance performance improvement with manufacturing practicality
Solution Approach 2:
The patent applies specific functional group distributions within the adhesive agent layer to optimize local drug release properties while maintaining overall manufacturing simplicity. The functional groups are concentrated in the adhesive layer where they provide maximum benefit for skin permeability without complicating the overall patch manufacturing process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch achieves improved skin permeability of ropinirole, maintaining cohesive force and adhesiveness while ensuring uniform distribution of the drug.
Implementation Method 1
In a patch comprising a backing layer and an adhesive agent layer, the adhesive agent layer comprising: at least one selected from the group consisting of ropinirole and a pharmaceutically acceptable salt thereof; at least one sodium carboxylate selected from the group consisting of sodium pentanoate, disodium glutarate, and sodium hexanoate; and an adhesive agent
Data Source
AI summary
A ropinirole-containing patch comprising a backing layer and an adhesive agent layer, whereinthe adhesive agent layer comprising:at least one selected from the group consisting of ropinirole and a pharmaceutically acceptable salt thereof;at least one sodium carboxylate selected from the group consisting of sodium pentanoate, disodium glutarate, and sodium hexanoate; andan adhesive agent.