ROS-Affinity Capsule Matrix for Targeted Antioxidant Delivery
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Solution Overview
Problem
Current skin care products with antioxidant active ingredients incorporated in oxidization-stable matrices fail to target areas with high concentrations of Reactive Oxygen Species (ROS) effectively, as these matrices lack affinity towards ROS and require the use of toxic organic solvents and high temperatures for production.
Innovation Solution
Development of skin care products containing capsules with a matrix rich in unsaturated fatty acids and antioxidant agents, which have a high affinity towards ROS, allowing targeted delivery of active ingredients to areas with ROS, and a production method that avoids organic solvents and high temperatures by using a process involving melting, dispersion, emulsion formation, and controlled cooling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If oxidization-stable matrices are used to protect and convey active ingredients, then the stability and controlled release of active ingredients is improved, but the affinity towards ROS is reduced, preventing targeted delivery to ROS-rich areas
Solution Approach 1:
The patent changes the chemical composition parameters of the capsule matrix by incorporating oxidizable lipids (such as phospholipids and cholesterol) with specific functional groups that can react with ROS. This parameter change enables the matrix to have both stability for controlled release and high affinity for ROS, resolving the contradiction between protective stability and targeted responsiveness.
Solution Approach 2:
The patent creates a composite capsule matrix combining oxidizable lipids, surfactants, and active ingredients. This composite structure provides both the structural integrity needed for stable conveyance and the chemical reactivity required for ROS affinity, allowing the system to simultaneously achieve protected delivery and targeted release in ROS-rich areas.
2Ease of manufacture
If conventional production methods are used with organic solvents and high temperatures, then the manufacturing process is simplified, but the safety and quality of the final product deteriorates due to potential degradation of active ingredients
Solution Approach 1:
The patent changes the production parameters by using mild temperatures (below 40°C), aqueous environments instead of organic solvents, and gentle mixing speeds (100-200 rpm). These parameter changes eliminate harmful effects on active ingredients while maintaining manufacturing feasibility through a modified but still practical process.
Solution Approach 2:
The patent replaces harsh chemical and thermal processing methods with gentle mechanical emulsification and aqueous-based formulation. This substitution eliminates the need for toxic organic solvents and high-temperature processing, protecting active ingredients from degradation while achieving effective capsule formation.
3Reliability
If high concentrations of active ingredients are used to ensure effectiveness, then the antioxidant activity is improved, but the cost of production increases
Solution Approach 1:
The patent applies local quality by concentrating active ingredients within the capsule structure where they are needed most - in ROS-rich areas of the skin. The capsules deliver high local concentrations of antioxidants precisely where oxidative stress occurs, rather than requiring high concentrations throughout the entire product formulation, thus reducing overall ingredient costs while maintaining effectiveness.
Solution Approach 2:
The patent enables the capsule matrix to automatically respond to ROS presence through oxidizable lipid components that react preferentially in high-ROS environments. This self-service mechanism ensures active ingredients are released and activated only where needed, maximizing their effectiveness at lower overall concentrations and reducing production costs.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The skin care product effectively targets ROS-rich areas, providing enhanced antioxidant delivery while being produced at a competitive cost and with improved safety and efficiency, overcoming the limitations of existing products.
Implementation Method 1
melting a solid lipophilic part at approximately 50±5 degrees Celsius, obtaining a melted lipophilic part
Implementation Method 2
combining said melted lipophilic part with said cooled aqueous solution or suspension, under stable agitation, obtaining an emulsion
Implementation Method 3
cooling said aqueous solution or suspension to a temperature lower than 10 degrees Celsius, obtaining a cooled aqueous solution or suspension
Implementation Method 4
drying said microemulsion in a vacuum at a controlled temperature lower than 40 degrees Celsius
Data Source
AI summary
This invention is a skin care product and method for making same. The skin care product includes at least one capsule, the capsule comprising a matrix, one or more active ingredients incorporated or contained in the matrix, where at least the matrix has a high affinity with Reactive Oxygen Species (ROS). In an embodiment of the invention, at least one antioxidant agent is incorporated in the matrix. A capsule is a lipid particle. In an embodiment of the invention, the skin care product comprising the capsules is used for topical inhibition of Reactive Oxygen Species ROS in the skin of a person. A method for making the capsule is also disclosed.