Rose-Derived Exosomes for Boosting Animal Cell Exosome Secretion

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Solution Overview

Problem

There is a need for a method to enhance exosome secretion from animal cells, as existing research on rose-derived exosomes has not fully explored their potential in promoting this process.

Innovation Solution

Treating animal cells with rose-derived exosomes, such as those isolated from rose plant cells or stem cells, in a culture medium to stimulate exosome secretion.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If animal cells are treated with rose-derived exosomes in culture medium, then exosome secretion from animal cells is significantly increased, but the complexity of the culture system increases

Engineering Contradiction:
Improveexosome secretion amountVSAvoidculture system complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

Rose-derived exosomes serve as an intermediary substance that mediates the enhancement of exosome secretion from animal cells. These exosomes are isolated from rose plant cells or rose stem cells and added to the culture medium, where they act as signaling molecules to stimulate the target animal cells to secrete more exosomes, thereby resolving the contradiction by introducing a natural mediator that boosts productivity without requiring complex system modifications

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention changes the compositional parameter of the culture medium by adding rose-derived exosomes. This parameter change (adding a specific biological substance) directly affects the secretion behavior of animal cells, increasing exosome production. The method optimizes the concentration and source of rose-derived exosomes to achieve maximum secretion enhancement while maintaining culture system simplicity

Inventive Principle:
Principle #35Parameter changes

2Reliability

If rose-derived exosomes are used to promote exosome secretion, then cell-to-cell communication is enhanced, but the cost of reagents increases

Engineering Contradiction:
Improvecell-to-cell communication efficiencyVSAvoidreagent cost
Core Design Contradiction:
ReliabilityVSQuantity of substance

Solution Approach 1:

The invention utilizes rose-derived exosomes as a cost-effective reagent. Rose plants are commonly cultivated and their cellular byproducts can be obtained relatively inexpensively compared to using animal-derived or synthetic alternatives. The exosomes from rose cells serve as a disposable, low-cost signaling agent that can be added to culture media to enhance cell-to-cell communication without requiring expensive reagents, thus resolving the contradiction between reliability and cost

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Data Source

PatentUS20250368951A1Method for promoting secretion of exosomes from animal cells by using rose-derived exosomes
Publication Date: 2025.12.04 EXOCOBIO INC
  • US20250368951A1 patent drawing
  • US20250368951A1 patent drawing
  • US20250368951A1 patent drawing

AI summary

A method for promoting exosome secretion from animal cells is provided. The method includes treating the animal cells with rose-derived exosomes. The method can promote the secretion of exosomes from animal cells by treating the animal cells with rose-derived exosomes.