Rosmarinic Acid Stabilization for Lung Function
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Solution Overview
Problem
There is an unmet need for effective natural ingredients or combinations to improve lung function in compromised individuals and promote healthy aging of the lungs, as existing senolytic drugs have limitations, and Rosmarinic acid degrades rapidly during extraction from plant parts, reducing yields.
Innovation Solution
A composition comprising Rosmarinic acid and Nigella sativa extract standardized to contain at least 5% w/w thymoquinone, along with a novel method for stabilizing Rosmarinic acid and preparing plant material from the Lamiaceae family for isolation, including acid treatment and solvent-based extraction processes to enhance yield and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If Rosmarinic acid is extracted from plant parts using conventional methods, then the extraction process is simple, but Rosmarinic acid degrades rapidly reducing the yield
Solution Approach 1:
The patent applies preliminary action by treating plant material with acid before extraction to stabilize Rosmarinic acid and prevent degradation during the extraction process. This pre-treatment step ensures the compound remains stable throughout subsequent processing, thereby increasing yield.
Solution Approach 2:
The patent changes physical and chemical parameters by controlling pH levels during extraction and using specific solvent systems. By adjusting these parameters, the extraction process maximizes Rosmarinic acid yield while maintaining its stability throughout the procedure.
2Reliability
If existing senolytic drugs are used to counter lung ageing, then some show promise in preclinical studies, but they have limitations in effectiveness and safety for clinical use
Solution Approach 1:
The patent uses natural plant-derived compounds (Rosmarinic acid and Nigella sativa extract) as alternatives to complex synthetic senolytic drugs. These natural compounds provide the desired therapeutic effect with better safety profiles, effectively replacing problematic pharmaceutical agents.
Solution Approach 2:
The patent combines multiple natural compounds (Rosmarinic acid from Lamiaceae family plants and Thymoquinone from Nigella sativa) to create a synergistic composition. This composite approach enhances therapeutic effectiveness while maintaining safety, overcoming limitations of single-compound treatments.
3Ease of manufacture
If plant material is dried and stored for later extraction, then storage is convenient, but Rosmarinic acid degrades during storage reducing total yield
Solution Approach 1:
The patent applies preliminary acid treatment to plant material before drying and storage. This pre-treatment stabilizes Rosmarinic acid, allowing the material to be stored conveniently without significant degradation, thus preventing substance loss while maintaining storage ease.
Solution Approach 2:
The patent creates a protective environment during storage by using acid-treated plant material that is more resistant to degradation. This effectively creates a chemically protective atmosphere that prevents oxidative and enzymatic degradation of Rosmarinic acid during storage.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively improves lung function and delays lung senescence by increasing tidal volume, minute ventilation, transdiaphragmatic pressure, and immunoglobulin A levels, while reducing senile emphysema and cellular senescence markers, thereby addressing compromised lung function and aging.
Implementation Method 1
due to its unstable nature, it degrades rapidly from the plant parts during the process of drying and storage, thereby reducing the total yields of Rosmarinic acid during extraction. The present invention solves the above industrial problem by disclosing a novel method for stabilizing the content of Rosmarinic acid in the plant material
Implementation Method 2
a novel method for stabilizing Rosmarinic acid and preparing plant material from the Lamiaceae family for isolation, including acid treatment and solvent-based extraction processes to enhance yield and stability
Data Source
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AI summary
The present invention discloses a process of isolating Rosmarnic acid and a composition comprising Rosmarinic acid and Nigella sativa extract standardised to contain not less than 5% w/w thymoquinone. More specifically, the invention discloses the use of a composition comprising Rosmarinic acid and Nigella sativa extract standardised to contain not less than 5% w/w thymoquinone in improving lung function and delaying lung senescence in aging mammals.