Rotary Gene Diagnosis Chip Layout for Longer DNA/RNA Capture
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Solution Overview
Problem
Existing rotational genetic diagnosis devices face inefficiencies in sample pretreatment due to insufficient time for DNA/RNA adsorption onto beads and limitations in sample capacity, leading to reduced diagnostic efficiency and difficulty in performing large-capacity diagnoses.
Innovation Solution
A rotational genetic diagnosis device with a genetic diagnosis chip that includes a pretreatment unit with a sample loading unit directly formed on the capture channel, allowing for extended adsorption time, and a distribution unit with reaction chambers for PCR or RT-PCR, enhancing sample pretreatment efficiency and diagnostic capacity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Volume of moving object
If the sample loading unit is located radially inward from the bead channel, then the device structure is compact, but the DNA/RNA adsorption time is insufficient and sample pretreatment efficiency is reduced
Solution Approach 1:
The patent inverts the radial position relationship between the sample loading unit and bead channel. Instead of placing the sample loading unit radially inward from the bead channel, the sample loading unit is positioned radially outward from the bead channel. This inversion allows the sample to flow through the bead channel for a longer duration, increasing DNA/RNA adsorption time and improving sample pretreatment efficiency while maintaining compact device structure.
2Productivity
If the chamber containing waste liquid is used for large-capacity diagnoses, then the sample processing capacity should be sufficient, but a sufficient amount of sample solution cannot be contained
Solution Approach 1:
The patent segments the fluid handling system into multiple independent channels: a sample solution channel, a waste liquid channel, and a pretreatment channel. By separating the sample solution containment function from the waste liquid containment function, the device can accommodate sufficient sample solution volume for large-capacity diagnoses without being limited by the waste liquid chamber capacity. The sample solution is contained in dedicated reservoirs that are independent of the waste liquid chamber.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The improved device achieves enhanced sample pretreatment efficiency and enables simultaneous diagnosis of multiple viruses, addressing the limitations of existing devices in terms of time and capacity.
Implementation Method 1
a capture channel which captures the target material from the loaded sample
Implementation Method 2
a washing liquid for washing materials excluding the target material captured in the capture channel
Implementation Method 3
an eluent for separating the target material captured in the capture channel
Implementation Method 4
a delay unit provided between the capture channel and the washing liquid storage unit and configured to delay passage of the washing liquid
Implementation Method 5
an oil chamber which is located radially inward from the input channel to communicate with the input channel and in which an oil input to the input channel to prevent evaporation of the mixture
Data Source
AI summary
Disclosed is a genetic diagnosis chip. The genetic diagnosis chip includes one or more unit processing parts, wherein the unit processing part includes a pretreatment unit that loads a sample and performs a pretreatment process on a target material in the loaded sample, and a distribution unit which is located radially outward from the pretreatment unit and in which the target material pretreated through the pretreatment unit is distributed and detection of the distributed target material is performed, the pretreatment unit includes a sample loading unit that loads the sample, and a capture channel which captures the target material from the loaded sample, and the sample loading unit is formed on the capture channel.