Rotary Sampling Platform for High-Throughput Bulk Solid MS
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Solution Overview
Problem
Existing sampling technologies face challenges in efficiently and effectively analyzing analytes in bulk solids using mass spectrometry, particularly in laboratory-based and field conditions, with a need for improved high-throughput sample analysis and integration with portable mass spectrometers.
Innovation Solution
A sampling platform system incorporating 3D-printed cone spray ionization mass spectrometry (3D-PCSI-MS) sources, which includes a sample collection device made of conductive polymer and a rotary disc-shaped apparatus with receptacles for holding sample collection devices, coupled with a motorized platform and a mass spectrometer, enabling high-voltage application and solvent extraction for analyte detection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional sampling technologies are used for analyzing analytes in bulk solids, then the analysis can be performed, but the throughput and efficiency are insufficient for high-throughput sample analysis
Solution Approach 1:
The sampling platform is divided into multiple receptacles arranged in a circular array, with each receptacle holding a separate sample collection device. This segmentation allows multiple samples to be processed simultaneously or in rapid sequence, significantly increasing throughput compared to analyzing one sample at a time.
Solution Approach 2:
The platform incorporates a motorized rotation mechanism that dynamically positions different receptacles at the analysis station. This dynamic positioning enables automated sequential analysis of multiple samples without manual intervention, improving both throughput and reducing analysis time.
2Adaptability or versatility
If conventional sampling methods are used, then sample collection is possible, but the integration with portable mass spectrometers for field conditions is limited
Solution Approach 1:
The sampling platform is designed with universal interfaces and a standardized configuration that can be integrated with portable mass spectrometers. The motorized rotation system and receptacle array can accommodate different sample collection devices, making the system adaptable to various field conditions and instrument configurations without requiring complete system redesign.
3Productivity
If manual sample analysis is performed, then each sample can be analyzed individually, but the efficiency and performance for bulk solid analyte detection are reduced
Solution Approach 1:
The platform incorporates automated sample indexing and positioning mechanisms that self-adjust to present the correct receptacle to the mass spectrometer. The motorized rotation system automatically sequences through multiple samples without requiring manual repositioning, thereby improving efficiency while maintaining ease of operation through automated control.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enhances the throughput and efficiency of analyte detection in bulk solids, providing increased performance in both laboratory and field conditions by facilitating rapid and reliable analysis of solid media samples using portable mass spectrometry.
Implementation Method 1
3D-printed cone spray ionization mass spectrometry (3D-PCSI-MS) sources
Implementation Method 2
sample collection device made of conductive polymer, coupled with a motorized platform and a mass spectrometer, enabling high-voltage application
Implementation Method 3
facilitating rapid and reliable analysis of solid media samples
Data Source
AI summary
The embodiments are directed to both sampling apparatuses and systems. Apparatus embodiments are directed to a sample collection apparatus having several receptacles configured to removably-hold sample collection devices. The sample collection devices are configured to hold a sample including solid media and analyte. System embodiments include the sample collection apparatus and several receptacles for removably-holding sample collection devices. The system embodiments also include additional components to perform analysis of the sample.