Rotary Analysis Substrate Chamber Layout for Uniform Bead Mixing
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Solution Overview
Problem
Conventional sample analysis substrates suffer from decreased measurement precision due to insufficient mixing of liquid containing a specimen with magnet beads, limiting the binding of specific substances and affecting detection accuracy.
Innovation Solution
A sample analysis substrate with a novel structure featuring a reaction chamber that includes a capillary portion and a non-capillary portion, allowing for sufficient mixing of the liquid containing the specimen and magnet beads, enhancing the homogeneity of reactions and improving measurement precision.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a conventional sample analysis substrate is used, then the device structure is simple, but the measurement precision is decreased due to insufficient mixing
Solution Approach 1:
The reaction chamber is segmented into a capillary portion and a non-capillary portion, creating distinct functional zones. The capillary portion ensures complete liquid absorption and initial mixing, while the non-capillary portion provides space for homogeneous reaction without overflow, thereby improving measurement precision through structured segmentation.
Solution Approach 2:
Different portions of the reaction chamber are赋予 different properties: the capillary portion has high surface-area-to-volume ratio for efficient liquid absorption and initial mixing, while the non-capillary portion provides a larger volume for complete reaction. This local differentiation of properties enables both thorough mixing and homogeneous reaction.
2Measurement precision
If the reaction chamber is enlarged to allow sufficient mixing, then the mixing effectiveness is improved, but the liquid may overflow and contaminate other chambers
Solution Approach 1:
The reaction chamber is divided into two portions: the capillary portion absorbs and contains the liquid sample completely, preventing overflow. The non-capillary portion provides additional space for reaction without risk of contamination to other chambers, thus eliminating the harmful effect of liquid overflow.
Solution Approach 2:
The capillary portion acts as an intermediary that first absorbs and contains the liquid sample, ensuring complete mixing. Then the reaction solution is transferred to the non-capillary portion for the reaction. This intermediary structure prevents direct contact and potential overflow into other chambers.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The novel structure enables more homogeneous reactions, enabling highly precise measurements by ensuring thorough mixing and binding of substances, thereby improving detection accuracy.
Implementation Method 1
The space includes a capillary portion and a first non-capillary portion connected with the capillary portion
Data Source
Figure 1~2A
Figure 2B~3A
Figure 3B
AI summary
This substrate for sample analysis, which transfers a sample-containing liquid by means of rotation and analyzes a specific substance in a sample, is provided with: a space (106r) which holds the sample-containing liquid in a substrate having a rotary shaft; a reaction chamber (161) having an inlet (106ri) and an outlet (106ro) connected to the space; and a dried reagent (125) disposed in the space (106r) of the reaction chamber (161). The space (106r) has a first end (106r1) and a second end (106r2) spaced apart from each other in a circumferential direction. The inlet (106ri) and the outlet (106ro) are arranged at the first end (106r1) and the second end (106r2), respectively. The space (106r) has a capillary portion (136re), and a first non-capillary portion (136rf1) which is connected to the capillary portion (136re), is located at the second end (106r2), has an opening, and extends in a radial direction. The outlet (106ro) is connected to the outer peripheral side of the first non-capillary portion (136rf1).