Rotating Chip Holder for Uniform Liquid Distribution in Micro-Flow Analysis
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Solution Overview
Problem
Conventional sample analysis devices face challenges in rapidly and accurately analyzing multiple components using a small amount of target liquid, particularly in uniformly introducing liquid into micro-flow paths during processes like ELISA, which requires repeated injections and improves measurement efficiency.
Innovation Solution
A sample analysis device with a chip holder and pipetting mechanism that rotates the analysis chip, allowing for uniform injection of target liquid into multiple micro-flow paths using capillary action, combined with an air injection mechanism to facilitate rapid and accurate analysis of multiple items.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If target liquid is introduced into micro-flow paths by capillary action, then the amount of target liquid required is reduced, but the uniformity of liquid distribution into multiple micro-flow paths deteriorates
Solution Approach 1:
The chip holder is rotated during the liquid introduction process to dynamically change the relative positions of the injection port and multiple micro-flow paths. This rotation ensures that liquid is uniformly distributed across all micro-flow paths while maintaining capillary action, thus resolving the contradiction between reducing liquid quantity and improving distribution uniformity.
2Measurement precision
If repeated injections are performed for ELISA analysis, then measurement accuracy is improved, but measurement time increases
Solution Approach 1:
The analysis chip is divided into multiple independent micro-flow paths, each capable of performing ELISA analysis simultaneously. By introducing liquid into multiple micro-flow paths in a single injection through rotation, the system achieves parallel processing of multiple samples or multiple analysis steps, thereby improving measurement accuracy through repeated injections while reducing total measurement time.
Solution Approach 2:
The chip holder rotation mechanism enables continuous introduction of liquid into multiple micro-flow paths without interruption. This continuous action allows repeated injections to be performed efficiently across multiple channels simultaneously, maintaining measurement accuracy while minimizing the time loss associated with sequential processing.
3Adaptability or versatility
If multiple reactants are stored in separate storage parts, then analysis versatility is improved, but device complexity increases
Solution Approach 1:
Multiple storage parts containing different reactants are integrated into a single analysis chip structure with a common injection port. The chip holder rotation mechanism merges the function of multiple separate storage and injection systems into one unified device, allowing versatile analysis of multiple components while simplifying the overall device architecture.
Solution Approach 2:
The analysis chip is designed as a multi-functional platform that can store and process multiple different reactants simultaneously. Each micro-flow path can be configured with different reactants for analyzing various components in target liquid, providing universal analysis capability without requiring separate dedicated devices for each analysis type.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid and accurate analysis of multiple components by ensuring uniform liquid distribution and efficient discharge from micro-flow paths, reducing measurement time and improving analysis efficiency.
Implementation Method 1
a flow path connected to the injection port and allowing introduction of the target liquid into the flow path by means of capillary action
Data Source
AI summary
Provided is a sample analyzing apparatus with which multiple analyses can be performed at the same time in a rapid and accurate manner using a small quantity of a liquid to be measured. This biochemical analyzing apparatus (50) is provided with a chip holder (53) into which an analysis chip (10) can be installed, a chip holder rotation unit (54) for rotating the chip holder (53), a pipetting unit (90) for injecting a candidate liquid into injection ports (22) in the analysis chip (10), and a measurement unit (80) capable of collectively measuring the respective reactions of the candidate liquid and multiple types of antigens (30). The chip holder (53) is rotated by the chip holder rotation unit (54), and injection of the candidate liquid is performed by the pipetting unit (90).