Rotating Optical Assembly for Biochip Scanning
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Solution Overview
Problem
Conventional sensing apparatuses are limited in their ability to quickly and efficiently scan samples with multiple test sites arranged in non-rectilinear patterns, such as spirals or arcs, and require movement of the sample or apparatus to read each test site individually, which slows down data collection and limits flexibility.
Innovation Solution
A sensing apparatus with a rotatable optical assembly that directs excitation light to multiple locations on a sample without moving the sample, combined with a linear stage to move the sample, allowing for simultaneous detection of emitted light from multiple locations, enabling rapid scanning of biochips and other samples with non-rectilinear test sites.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional sensing apparatuses use linear or grid motion to scan each test site individually, then measurement precision is maintained, but productivity decreases due to slow data collection
Solution Approach 1:
The patent applies dynamics by transitioning from static linear scanning to dynamic rotational scanning. The optical assembly rotates about an axis to rapidly illuminate multiple test sites in a circular pattern, enabling simultaneous detection of multiple locations and significantly increasing data collection speed while maintaining detection accuracy through controlled rotational motion
Solution Approach 2:
The patent introduces a rotational dimension to the scanning process. Instead of moving only in linear x-y directions, the system adds rotational movement about a vertical axis, allowing the optical assembly to access multiple test sites arranged in circular or spiral patterns, thereby increasing productivity without compromising measurement precision
2Ease of operation
If conventional sensing apparatuses are configured for rectilinear scanning, then ease of operation is maintained, but adaptability decreases for non-rectilinear test site arrangements
Solution Approach 1:
The patent achieves universality by designing an optical assembly that can perform both linear scanning and rotational scanning operations. The system can adapt to different test site arrangements (rectilinear, circular, spiral) by switching between scanning modes, making it versatile for various sample configurations while maintaining ease of operation through automated control
Solution Approach 2:
The system dynamically adjusts its scanning pattern based on the sample configuration. The optical assembly can switch between linear motion for grid arrangements and rotational motion for circular arrangements, providing adaptability to different test site patterns while maintaining operational simplicity through automated pattern selection
3Measurement precision
If samples are moved in rectilinear fashion for scanning, then measurement precision is maintained, but loss of time increases due to sequential testing
Solution Approach 1:
The patent implements continuous useful action by enabling simultaneous illumination and detection at multiple test sites during rotational scanning. As the optical assembly rotates, multiple detectors continuously capture fluorescence signals from different angular positions, eliminating the sequential waiting time inherent in linear scanning and significantly reducing total scanning duration
Solution Approach 2:
The system uses dynamic rotational motion to continuously access multiple test sites without the start-stop motion required in linear scanning. The rotational movement allows the optical assembly to smoothly transition between test sites while detectors continuously collect data, reducing idle time and accelerating the overall sensing process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly reduces the time required to sense samples with multiple test sites, enhances flexibility in sample arrangement, and allows for continuous scanning without the need for rectilinear movement, improving data collection efficiency and sample handling.
Implementation Method 1
Biochip scanners, for example, use laser light to irradiate a chemical or biological sample, which, depending on material in the sample, responds by fluorescing.
Data Source
AI summary
An apparatus for optical sensing of samples includes an optical source, an optical assembly being rotatable about an axis, a sample holder, and a detector. The optical assembly rotates, allowing the sensing apparatus to sense results from plural locations on a sample without moving the sample. Moving the sample in a linear direction while rotating the optical assembly allows sensing of an entire sample containing multiple test sites, such as a biochip. An optical assembly containing mirrors to direct light from the optical source to the sample is provided. Preferably, light enters the optical assembly along the axis of rotation. Sensing methods consistent with the invention are also described.