Rotating Sample Device Optical Material Detection

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Existing sample processing devices face challenges in accurately determining whether a selected volume of material is present in a detection chamber, leading to potential false assay results due to errors in material transfer during processing.

Innovation Solution

A method and system for optically interrogating a detection chamber on a rotating sample processing device to determine the presence of a material, involving a comparison of background and post-rotation scans to verify material transfer and presence.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If optical interrogation is performed on a rotating sample processing device, then material presence detection capability is improved, but device complexity increases

Engineering Contradiction:
Improvematerial presence detectionVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

A reflector is introduced as an intermediary component between the light source and the detection chamber. The reflector redirects light to illuminate the detection chamber from a different angle, enabling material presence detection without requiring direct optical access during rotation. This mediator allows the system to achieve detection capability while maintaining rotational operation.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent introduces a temporal dimension to the optical interrogation by performing scans at different rotational positions. Background scans are taken at one rotational position and post-rotation scans are taken after the chamber has rotated into position. By comparing these scans taken at different times and rotational positions, the system can detect material presence without requiring direct optical access during the entire rotation cycle.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

2Measurement precision

If background and post-rotation scans are compared to verify material transfer, then measurement precision is improved, but loss of time increases

Engineering Contradiction:
Improvematerial transfer verificationVSAvoidprocessing time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

Background scans are performed in advance, before the actual sample processing and rotation sequence begins. These preliminary scans establish a baseline that can be later compared against post-rotation scans. By performing this reference measurement beforehand, the system avoids adding time to the critical processing path while still enabling verification of material transfer.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The optical scanning operation continues uninterrupted during the rotation process. The system maintains continuous scanning capability, taking background scans, then rotating the detection chamber into position, and immediately capturing post-rotation scans. This continuous operation minimizes idle time and ensures that the verification process is tightly integrated with the processing workflow rather than being a separate sequential step.

Inventive Principle:
Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Ensures accurate validation of assay results by confirming material presence in the detection chamber, preventing false negatives and interrupting or invalidating runs if material is not properly transferred.

Implementation Method 1

optically interrogating a detection chamber on a rotating sample processing device to determine the presence of a material

Methodology Applied
Scientific EffectOptical property detection: Absorption Spectroscopy

Data Source

PatentEP2709762B1Systems and methods for detecting the presence of a selected volume of material in a sample processing device
Publication Date: 2021.03.31 DIASORIN ITALIA SPA
  • EP2709762B1 patent drawingFigure 1
  • EP2709762B1 patent drawingFigure 2
  • EP2709762B1 patent drawingFigure 3~4

AI summary

Systems and methods for processing sample processing devices. The system can include a sample processing device comprising a detection chamber, a motor configured to rotate the sample processing device about an axis of rotation, and an optical module operatively positioned relative to the sample processing device and configured to determine whether a selected volume of material is present in the detection chamber of the sample processing device. The method can include rotating the sample processing device about an axis of rotation, and determining whether a selected volume of material is present in the detection chamber, while rotating the sample processing device. In some embodiments, determining whether a selected volume of material is present can be performed by optically interrogating the detection chamber for an optical property of the material.