Rotating Sample Device Optical Material Detection
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Solution Overview
Problem
Existing sample processing devices face challenges in accurately determining whether a selected volume of material is present in a detection chamber, leading to potential false assay results due to errors in material transfer during processing.
Innovation Solution
A method and system for optically interrogating a detection chamber on a rotating sample processing device to determine the presence of a material, involving a comparison of background and post-rotation scans to verify material transfer and presence.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If optical interrogation is performed on a rotating sample processing device, then material presence detection capability is improved, but device complexity increases
Solution Approach 1:
A reflector is introduced as an intermediary component between the light source and the detection chamber. The reflector redirects light to illuminate the detection chamber from a different angle, enabling material presence detection without requiring direct optical access during rotation. This mediator allows the system to achieve detection capability while maintaining rotational operation.
Solution Approach 2:
The patent introduces a temporal dimension to the optical interrogation by performing scans at different rotational positions. Background scans are taken at one rotational position and post-rotation scans are taken after the chamber has rotated into position. By comparing these scans taken at different times and rotational positions, the system can detect material presence without requiring direct optical access during the entire rotation cycle.
2Measurement precision
If background and post-rotation scans are compared to verify material transfer, then measurement precision is improved, but loss of time increases
Solution Approach 1:
Background scans are performed in advance, before the actual sample processing and rotation sequence begins. These preliminary scans establish a baseline that can be later compared against post-rotation scans. By performing this reference measurement beforehand, the system avoids adding time to the critical processing path while still enabling verification of material transfer.
Solution Approach 2:
The optical scanning operation continues uninterrupted during the rotation process. The system maintains continuous scanning capability, taking background scans, then rotating the detection chamber into position, and immediately capturing post-rotation scans. This continuous operation minimizes idle time and ensures that the verification process is tightly integrated with the processing workflow rather than being a separate sequential step.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Ensures accurate validation of assay results by confirming material presence in the detection chamber, preventing false negatives and interrupting or invalidating runs if material is not properly transferred.
Implementation Method 1
optically interrogating a detection chamber on a rotating sample processing device to determine the presence of a material
Data Source
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AI summary
Systems and methods for processing sample processing devices. The system can include a sample processing device comprising a detection chamber, a motor configured to rotate the sample processing device about an axis of rotation, and an optical module operatively positioned relative to the sample processing device and configured to determine whether a selected volume of material is present in the detection chamber of the sample processing device. The method can include rotating the sample processing device about an axis of rotation, and determining whether a selected volume of material is present in the detection chamber, while rotating the sample processing device. In some embodiments, determining whether a selected volume of material is present can be performed by optically interrogating the detection chamber for an optical property of the material.