Rotational Combinatorial Therapies to Prevent Desensitization
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Solution Overview
Problem
Existing treatments for obesity and other chronic conditions often result in limited or unsustainable weight loss and can lead to desensitization due to prolonged use, necessitating the development of therapies that target multiple pathways and avoid desensitization.
Innovation Solution
Administering rotational combinatorial regimens that involve alternating combinations of at least two different drugs targeting distinct pathways or intervention targets for chronic conditions, ensuring each combination is administered at least once per cycle and repeated multiple times.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If a single drug or treatment is administered continuously for chronic conditions, then the treatment duration can be extended, but desensitization occurs reducing therapeutic effectiveness
Solution Approach 1:
The patent implements periodic action by rotating between multiple different drug combinations in a systematic manner. Each combination is administered for a predetermined period, then switched to the next combination in the sequence. This periodic rotation prevents continuous exposure to the same therapeutic agents, thereby avoiding desensitization while maintaining extended treatment duration for chronic conditions.
Solution Approach 2:
The patent applies dynamics by making the treatment regimen adaptable and changeable over time. Instead of a static single-drug regimen, the treatment dynamically transitions between multiple drug combinations. This dynamic approach allows the therapeutic strategy to evolve, preventing the body from adapting to a fixed treatment and maintaining reliability of therapeutic effectiveness throughout extended treatment periods.
2Reliability
If multiple drug combinations are rotated for chronic conditions, then desensitization is prevented, but the complexity of the treatment regimen increases
Solution Approach 1:
The patent applies segmentation by dividing the overall treatment into distinct modular drug combination units. Each combination consists of specific drugs targeting different pathways, and these modular combinations are rotated in a systematic sequence. This segmentation makes the complex multi-drug strategy manageable by organizing it into discrete, repeatable units that can be administered in a structured manner.
Solution Approach 2:
The patent implements universality by designing drug combinations that target multiple different pathways and mechanisms simultaneously. Each combination serves multiple therapeutic functions by incorporating drugs with different mechanisms of action, allowing a single combination to address multiple aspects of the chronic condition. This multi-functionality reduces the need for even more combinations, thereby managing overall regimen complexity.
3Reliability
If combinations of at least two different drugs targeting different pathways are administered, then therapeutic effectiveness is enhanced, but the quantity of substances administered increases
Solution Approach 1:
The patent applies merging by combining multiple drugs within each treatment combination that target different pathways and mechanisms. By merging these drugs into unified combinations administered together, the patent enhances therapeutic effectiveness through synergistic or additive effects. The drugs are merged into coordinated regimens that are rotated systematically, managing the quantity of substances through structured combination therapy rather than individual drug administration.
Data Source
AI summary
Therapies and regimens for treating chronic diseases, disorders, and conditions that have a plurality of intervention targets and/or therapeutic targets are provided. Therapies include administration combinatorial regimens, and administration of rotational combinatorial regimens. The regimens comprise combinations of drugs and/or non-drug treatments.