Rotational Sample Analysis Substrate with Pre-mixed Reagent Chamber
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Solution Overview
Problem
Current sample analysis methods require enhancement in measurement accuracy, particularly in the analysis of liquids using sample analysis substrates with rotational motions, where fluctuations in reactions between reagents and analytes can impact results.
Innovation Solution
A sample analysis substrate with a rotation axis, featuring a first retention chamber for a diluent, a measurement chamber, and a reagent chamber connected via a diluent path, allowing for controlled mixing and transfer of reagents and analytes to enhance measurement accuracy by suppressing reaction fluctuations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a sample analysis substrate uses rotational motion to transfer liquid, then liquid transfer and mixing can be achieved, but measurement accuracy is insufficient due to reaction fluctuations
Solution Approach 1:
The patent applies preliminary action by pre-mixing the reagent with diluent in the reagent chamber before the actual analysis. This pre-mixing ensures that the reagent is uniformly distributed and ready for immediate use, eliminating fluctuations that would occur during the analysis phase. The reagent solution is prepared in advance and stored in the reagent chamber, maintaining consistent concentration and composition throughout the measurement process.
Solution Approach 2:
The substrate is segmented into distinct functional chambers: a reagent chamber for preparing reagent solutions, a sample chamber for introducing analytes, and a measurement chamber for analysis. This segmentation allows independent optimization of each function - the reagent chamber focuses on uniform reagent preparation while the measurement chamber focuses on accurate detection, thereby improving both reaction stability and measurement precision.
2Productivity
If reagents are directly introduced into the measurement chamber, then analysis can proceed quickly, but reaction fluctuations reduce measurement accuracy
Solution Approach 1:
The reagent is pre-mixed with diluent in the reagent chamber before being introduced to the measurement chamber. This preliminary preparation ensures uniform reagent concentration, eliminating reaction fluctuations that would compromise measurement accuracy while maintaining efficient workflow through automated transfer mechanisms.
Solution Approach 2:
The diluent acts as an intermediary substance that facilitates uniform distribution of the reagent. By mixing the reagent with diluent in the reagent chamber before introduction to the measurement chamber, the diluent ensures homogeneous reagent solution that reacts consistently with the analyte, thereby improving measurement precision without sacrificing analysis speed.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The controlled mixing and transfer of reagents and analytes on the substrate improve measurement accuracy by ensuring uniform reaction conditions, reducing fluctuations and enhancing the reliability of analytical results.
Implementation Method 1
a sample analysis substrate in which transfer of a liquid is effected through rotational motions
Data Source
AI summary
A sample analysis substrate in which transfer of a liquid is effected through rotational motions, including: a substrate having a rotation axis; a first retention chamber being located in the substrate and retaining a diluent; a measurement chamber being located in the substrate; at least one reagent; a reagent chamber being located in the substrate and having the at least one reagent disposed therein, the reagent chamber being connected to the measurement chamber; and a first diluent path being located in the substrate, and connecting the first retention chamber and the measurement chamber or reagent chamber.