Enzyme-Treated Royal Jelly Stabilization via Polysaccharide Coating

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Solution Overview

Problem

Enzyme-treated royal jelly exhibits higher moisture absorption compared to untreated royal jelly, leading to particle cracking and reduced operability, and is prone to browning due to the Maillard reaction.

Innovation Solution

Incorporating carrageenan, dextrin, pullulan, gum arabic, or xanthan gum with enzyme-treated royal jelly during or after peptidase treatment, followed by freeze-drying, to suppress moisture absorption and coloring.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If enzyme treatment is applied to royal jelly to reduce allergens, then allergenicity is reduced, but moisture absorption increases

Engineering Contradiction:
ImproveallergenicityVSAvoidmoisture absorption
Core Design Contradiction:
Object-affected harmful factorsVSQuantity of substance

Solution Approach 1:

The patent introduces hydrophobic substances (silicone oil, vegetable oil, or animal oil) as intermediary substances that form a protective coating around the enzyme-treated royal jelly particles. This coating layer acts as a barrier that prevents moisture from being absorbed by the hydrophilic enzyme-treated royal jelly, thereby resolving the contradiction between reduced allergenicity and increased moisture absorption.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent creates a composite material system consisting of enzyme-treated royal jelly combined with hydrophobic substances. This composite structure combines the low-allergen properties of enzyme-treated royal jelly with the moisture-repellent properties of hydrophobic substances, achieving both reduced allergenicity and suppressed moisture absorption simultaneously.

Inventive Principle:
Principle #40Composite materials

2Object-affected harmful factors

If enzyme treatment is applied to royal jelly to reduce allergens, then allergenicity is reduced, but particle cracking occurs due to moisture absorption

Engineering Contradiction:
ImproveallergenicityVSAvoidparticle integrity
Core Design Contradiction:
Object-affected harmful factorsVSStrength

Solution Approach 1:

The hydrophobic substances serve as an intermediary protective layer that prevents moisture from penetrating into the royal jelly particles. By blocking moisture ingress, the treatment prevents the swelling and subsequent cracking of particles, thereby maintaining particle integrity while preserving the reduced allergenicity achieved through enzyme treatment.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent applies hydrophobic substances to royal jelly particles before they are exposed to humid environments. This preemptive coating provides protective cushioning that prevents moisture-induced stress and cracking, ensuring particle strength is maintained throughout storage and handling.

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

3Object-affected harmful factors

If enzyme treatment is applied to royal jelly to reduce allergens, then allergenicity is reduced, but browning occurs due to Maillard reaction

Engineering Contradiction:
ImproveallergenicityVSAvoidbrowning
Core Design Contradiction:
Object-affected harmful factorsVSObject-generated harmful factors

Solution Approach 1:

The hydrophobic coating acts as a physical barrier that limits the interaction between water and the royal jelly components. By restricting water availability, the coating suppresses the Maillard reaction between reducing sugars and amino groups, thereby preventing browning while maintaining the low-allergen properties of the enzyme-treated product.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Significantly reduces moisture absorption and prevents browning, thereby stabilizing the enzyme-treated royal jelly composition and improving its safety and usability.

Implementation Method 1

when enzyme-treated royal jelly is allowed to coexist with at least one member selected from the group consisting of carrageenan, dextrin, pullulan, gum arabic, and xanthan gum, the moisture absorption thereof over time can be significantly prevented

Methodology Applied
Scientific EffectAdsorption: Adsorption

Implementation Method 2

a method for suppressing moisture absorption of enzyme-treated royal jelly that occurs over time

Methodology Applied
Scientific EffectFreeze drying: Freeze Drying

Implementation Method 3

followed by freeze-drying

Methodology Applied
Scientific EffectSublimation: Sublimation

Implementation Method 4

decompose or lower the molecular weight of protein, which can be an allergen, to reduce the amount of allergen

Methodology Applied
Scientific EffectEnzyme hydrolysis: Hydrolysis

Implementation Method 5

subjecting royal jelly to a glycolytic enzyme treatment and a protease treatment

Methodology Applied
Scientific EffectEnzyme: Enzyme

Implementation Method 6

coloring proceeds under severe conditions, such as heating and humidification, resulting in browning. Such coloring is considered to be due to the Maillard reaction that occurs between the amide groups of peptides and amino acids fragmented by enzyme-treatment and the anomeric carbon of the reducing sugar

Methodology Applied
Scientific EffectMaillard reaction: Chemical Bonding

Data Source

PatentUS11998031B2Stabilization of enzyme treated royal jelly
Publication Date: 2024.06.04 YAMADA BEE COMPANY INC
  • US11998031B2 patent drawing

AI summary

Disclosed are an enzyme-treated royal jelly composition comprising carrageenan and enzyme-treated royal jelly treated with a peptidase; an enzyme-treated royal jelly composition comprising at least one member selected from the group consisting of galactomannan, galactomannan-containing polysaccharides, and xanthan gum, at least one member selected from the group consisting of carrageenan, dextrin, and pullulan, and enzyme-treated royal jelly treated with a peptidase; and an enzyme-treated royal jelly composition comprising dextrin, at least one member selected from the group consisting of carrageenan and pullulan, and enzyme-treated royal jelly treated with a peptidase.