Rubber Seed Oil Refining for Atherosclerosis Treatment Safety

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Solution Overview

Problem

Rubber seed crude oil has medicinal activity in reversing and ablating atherosclerosis but contains harmful and toxic components, and existing refining methods do not consider its medicinal activity, resulting in refined oils with little to no pharmacological effect.

Innovation Solution

A refining method involving alkali neutralization, centrifugal separation, adsorption filtration, and deodorization is used to produce a highly active and safe rubber seed oil that meets food safety standards and retains or exceeds the medicinal activity of crude oil.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If rubber seed crude oil is used directly for treating atherosclerosis, then medicinal activity is high, but safety is poor due to harmful and toxic components

Engineering Contradiction:
Improvemedicinal activityVSAvoidtoxic components
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent extracts and removes harmful components (free fatty acids, impurities) from rubber seed crude oil through alkali neutralization and filtration processes, retaining the beneficial medicinal components while eliminating toxicity

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent changes the chemical parameters of the oil by controlling the acid value from high (harmful) to low (safe) through alkali treatment, while maintaining the medicinal activity through optimized processing conditions

Inventive Principle:
Principle #35Parameter changes

2Object-affected harmful factors

If existing refining methods are used on rubber seed oil, then safety is improved, but medicinal activity is lost

Engineering Contradiction:
ImprovesafetyVSAvoidmedicinal activity
Core Design Contradiction:
Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent optimizes processing parameters (acid value control, temperature, pH) to remove harmful components while preserving medicinal components, achieving both safety and activity simultaneously

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent uses alkali as an intermediary substance to neutralize harmful free fatty acids without damaging the medicinal components, enabling selective removal of toxins while preserving therapeutic properties

Inventive Principle:
Principle #24Intermediary (Mediator)

3Object-affected harmful factors

If alkali neutralization is performed to reduce acid value, then safety is improved, but medicinal activity may be affected

Engineering Contradiction:
Improveacid valueVSAvoidmedicinal activity
Core Design Contradiction:
Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent precisely controls the alkali treatment parameters (amount of alkali, temperature, time, pH) to reduce acid value to safe levels while stopping before medicinal components are damaged, achieving optimal balance between safety and activity

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The refined rubber seed oil achieves significant safety compliance with edible oil standards and demonstrates enhanced or equal medicinal activity in preventing and treating atherosclerosis, making it suitable for pharmaceutical use.

Implementation Method 1

Mixing and reacting the rubber seed crude oil and the alkali aqueous solution under heating and stirring to perform neutralization reaction

Methodology Applied
Scientific EffectNeutralization reaction: Redox Reactions

Implementation Method 2

putting the neutralized mixture into a centrifugal separation device to perform phase separation between an oil phase and a water phase

Methodology Applied
Scientific EffectCentrifugal separation: Centrifugal Separation

Implementation Method 3

adding an adsorbent to the separated oil phase, stirring and filtering to perform adsorption filtration

Methodology Applied
Scientific EffectAdsorption: Adsorption

Data Source

PatentUS20240269214A1Substance having high activity and high safety, preparation method therefor, and application thereof in drug
Publication Date: 2024.08.15 SUZHOU HAIYI BIOMEDICAL TECH CO LTD
  • US20240269214A1 patent drawing
  • US20240269214A1 patent drawing
  • US20240269214A1 patent drawing

AI summary

This invention discloses a highly active and highly safe substance, its preparation method, and its use. This substance is prepared from rubber seed crude oil, through alkali neutralization, centrifugal separation, adsorption filtration, and deodorization. This substance is not only highly active in preventing and treating atherosclerosis than that of rubber seed crude oil; but also highly safe which can meet requirements in the national standard of food safety. The substance can be used in pharmaceuticals to prevent and treat atherosclerosis in patients with cardiovascular and cerebrovascular diseases.