Rubber Stopper Leakage Testing via Conical Displacement

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Solution Overview

Problem

Current methods for testing container closure integrity, particularly for drug containers sealed with rubber stoppers, lack a simple and reliable way to assess the leakage tolerance of the rubber stopper's movement relative to the container, which is crucial for ensuring the sterility and quality of stored drugs.

Innovation Solution

A device and method that utilize a displacement mechanism with a support member and a movement member, allowing for adjustable displacement of the rubber stopper relative to the drug container, enabling precise leakage testing by detecting the presence of a test medium through the dispensing opening.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a rubber stopper is used to seal a drug container, then the container can be closed and stored under sterile conditions, but the rubber stopper may be displaced from its sealing position during handling, causing leakage

Engineering Contradiction:
Improvecontainer closure integrityVSAvoidleakage due to stopper displacement
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the geometric parameters of the stopper and container interface by introducing a conical configuration. The stopper has a conical outer surface that mates with a conical inner surface in the container opening, creating a tapered interference fit that resists displacement forces while maintaining sealing integrity

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs composite sealing by combining the rubber stopper material with a conical geometric structure, and optionally combining multiple materials in the stopper itself (such as a rigid conical core with a flexible sealing layer) to achieve both mechanical retention and leakage prevention

Inventive Principle:
Principle #40Composite materials

2Measurement precision

If the rubber stopper is displaced to test leakage tolerance, then the leakage threshold can be determined, but the testing process becomes complex and time-consuming

Engineering Contradiction:
Improveleakage threshold detectionVSAvoidtesting apparatus complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent applies preliminary action by pre-configuring the stopper and container with complementary conical surfaces during manufacturing. This pre-established geometric relationship automatically provides the displacement resistance characteristic, eliminating the need for complex testing apparatus to simulate or measure stopper retention

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The conical geometry configuration enables the stopper-container assembly to self-test for leakage resistance. The tapered interference fit inherently resists displacement and maintains sealing, allowing simple visual or pressure-based testing without sophisticated equipment

Inventive Principle:
Principle #25Self-service

Data Source

PatentEP3884252B1Device and method for leakage testing of a connection between a rubber stopper and a corresponding drug container
Publication Date: 2023.01.04 LONZA AG
  • EP3884252B1 patent drawingFigure 1
  • EP3884252B1 patent drawingFigure 2
  • EP3884252B1 patent drawingFigure 3

AI summary

The invention concerns the field of container closure integrity (CCI) and the testing of CCI and relates to a device and a method for leakage testing of a connection between a rubber stopper and a corresponding drug container which can be used for storing drugs under sterile conditions and which is closed by said rubber stopper.