Rubusoside Purification via Temperature Gradient Crystallization
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Solution Overview
Problem
Current methods for purifying Rubusoside, such as chromatographic separation, are not feasible for large-scale production due to high solubility in water and organic solvents, limiting the production of high-purity Rubusoside.
Innovation Solution
A process involving temperature gradient treatment and multiple aqueous alcoholic solution steps with filtration and activated carbon treatment to achieve high-purity Rubusoside, with crystallization and drying to yield a product with >95% purity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If chromatographic separation is used to purify Rubusoside, then purity can be achieved, but the process is not feasible for large-scale production
Solution Approach 1:
The patent changes the purification approach by modifying physical parameters (temperature, solubility) rather than using chromatographic separation. By controlling temperature gradient and utilizing solubility differences in aqueous alcoholic solutions, the process achieves both high purity (>95%) and large-scale feasibility through crystallization and filtration steps
Solution Approach 2:
The patent replaces the mechanical chromatographic system with a thermal and solubility-based system. Instead of using columns and adsorbents, the process employs temperature-controlled crystallization, filtration, and activated carbon treatment to achieve purification, making it suitable for industrial scale
2Manufacturing precision
If conventional purification methods are used, then some purification is achieved, but high-purity Rubusoside cannot be produced at large scale
Solution Approach 1:
The patent segments the purification process into distinct operational steps: dissolution in aqueous alcoholic solution, temperature gradient treatment for crystallization, filtration, activated carbon treatment, and drying. This segmentation allows each step to be optimized independently and scaled effectively for high-purity production
Solution Approach 2:
The patent utilizes phase transitions, specifically crystallization from aqueous alcoholic solutions through temperature gradient control. This phase change enables the separation of Rubusoside from impurities and allows for high-purity product recovery at large scale, achieving >95% purity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This process efficiently produces high-purity Rubusoside suitable for use in food, beverages, and pharmaceuticals, overcoming the limitations of previous methods by achieving purity greater than 95% and enabling large-scale production.
Implementation Method 1
inducing crystallization in the first mixture by temperature gradient treatment
Implementation Method 2
adding activated carbon to the second mixture and filtering it to obtain decolorized second mixture
Data Source
AI summary
The invention provides a process of purifying Rubusoside from the Rubus suavissimus S. Lee plant extract. The process is useful for producing high purity Rubusoside with purity greater than 95% (dry basis). High purity rubusoside is useful as in combination with other caloric and non-caloric sweeteners as well as non-caloric sweetener in various food and beverage compositions. The high purity rubusoside is useful as non-caloric sweetener in edible and chewable compositions such as any beverages, confectioneries, bakeries, cookies, chewing gums, and alike.