Ruminococcus torques Polypeptides for Metabolic and Bone Health
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Solution Overview
Problem
Current treatments and prevention methods for metabolic, muscle, and bone disorders are inadequate, particularly for conditions like obesity, metabolic syndrome, and osteoporosis, as they do not effectively address the underlying metabolic and hormonal imbalances and bone health issues.
Innovation Solution
Polypeptides derived from Ruminococcus torques, including fragments and variants, are used as probiotics or Live Biopharmaceutical Products to treat and prevent these disorders by regulating host metabolism, muscle function, and bone health through specific amino acid sequences and interactions with integrin receptors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments for metabolic, muscle, and bone disorders are used, then current standard care is provided, but they do not effectively address underlying metabolic and hormonal imbalances and bone health issues
Solution Approach 1:
The patent uses probiotic bacteria (Ruminococcus torques) as an intermediary organism that produces bioactive peptides (RUCILP1 and RUCILP2) which then act on host integrin receptors to regulate metabolism, muscle function, and bone health. This intermediary approach allows the treatment to address underlying metabolic and hormonal imbalances rather than just treating symptoms.
Solution Approach 2:
The probiotic bacteria serve themselves by naturally producing the bioactive peptides as part of their metabolic functions. The bacteria's endogenous peptide production mechanisms are harnessed to provide therapeutic effects, eliminating the need for external administration of complex pharmaceutical compounds.
2Reliability
If polypeptides derived from Ruminococcus torques are used as probiotics or Live Biopharmaceutical Products, then treatment and prevention of metabolic, muscle, and bone disorders is achieved, but the complexity of identifying and producing specific functional peptides increases
Solution Approach 1:
The patent extracts and isolates specific functional peptides (RUCILP1 and RUCILP2) from the complex mixture of bacterial proteins produced by Ruminococcus torques. By focusing on these specific extracted peptides rather than administering whole bacteria or crude extracts, the treatment achieves reliable efficacy while simplifying production and quality control.
Solution Approach 2:
The patent segments the complex bacterial proteome into specific functional domains by identifying and isolating discrete peptide sequences (RUCILP1: SEQ ID NO: 4 and RUCILP2: SEQ ID NO: 19) that contain the therapeutic activity. This segmentation allows for targeted production and characterization of individual therapeutic peptides.
Data Source
AI summary
The present invention relates to polypeptides derived from Ruminococcus torques, and polypeptide fragments and variants thereof useful for treatment and/or prevention of metabolic disorders, muscle disorders and injuries, and bone disorders, and host cells comprising said polypeptides, polypeptide fragments or variants thereof for use as a probiotic or as a Live Biopharmaceutical Product (LBP).