S-Beta-Hydroxybutyrate Ester Composition for Sustained Ketosis
Solution Overview
Problem
Transitioning into and sustaining a ketogenic state is challenging due to the difficulty of depleting glucose stores, accompanied by hypoglycemia and electrolyte imbalances, which cause discomfort and metabolic downregulation, and existing compositions often omit or minimize the S-beta-hydroxybutyrate enantiomer.
Innovation Solution
Administering S-beta-hydroxybutyrate esters in enantiomerically pure or enriched form, particularly with a non-racemic mixture containing a higher percentage of S-beta-hydroxybutyrate, to promote and sustain ketosis, improve metabolic functions, and modulate electrolyte balance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing dietary and health practices are used to transition into ketosis, then ketotic state can be achieved, but the transition is challenging and accompanied by uncomfortable physiological and mental symptoms
Solution Approach 1:
The patent uses S-beta-hydroxybutyrate esters as an intermediary substance to facilitate the transition into ketosis. These esters serve as a precursor that the body converts into active ketone bodies, providing a bridge between dietary approaches and achieving reliable ketotic state without the harsh symptoms of direct fasting or extreme dietary restriction
Solution Approach 2:
The patent employs prodrug esters that undergo biochemical transformation in the body. The ester groups are removed through hydrolysis, converting the inactive prodrug form into the active S-beta-hydroxybutyrate ketone body, thereby changing the chemical parameter state to achieve therapeutic effects while avoiding direct administration of the active compound
2Ease of operation
If existing compositions are used to manage ketosis transition, then some symptomatic relief may be provided, but they fail to provide effective solutions for managing the transition and maintenance of ketosis
Solution Approach 1:
S-beta-hydroxybutyrate esters act as a mediator that addresses multiple aspects of ketosis management simultaneously. The ester formulation provides a controlled release mechanism that helps manage transition symptoms while reliably establishing and maintaining ketotic state, overcoming the limitations of existing compositions
Solution Approach 2:
The patent applies preliminary action by administering prodrug esters before full ketosis is established. These esters prepare the metabolic system for ketotic state by providing a gradual introduction of ketone bodies, thereby preventing the harsh transition symptoms that occur with abrupt dietary changes while ensuring reliable ketosis induction
Data Source
AI summary
Compositions for improving metabolic function in a subject include optically pure S-beta-hydroxybutyrate or non-racemic mixtures enriched with the S-enantiomer. S-beta-hydroxybutyrate in pure or enriched form provides energy to the heart, dilates the arteries, decreases blood pressure and systemic vascular resistance, and increases cardiac output. S-Beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. S-Beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and provide one or more electrolytes. S-Beta-hydroxybutyrate esters provide more controlled release without adding electrolytes. Compositions for improving heart function in a subject may contain a dietetically or pharmaceutically acceptable carrier and optically pure S-beta-hydroxybutyrate or non-racemic mixture enriched with S-beta-hydroxybutyrate, wherein the compositions contain from about 50.5% to 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and from about 49.5% to 0% by enantiomeric equivalents of R-beta-hydroxybutyrate.