S-Beta-Hydroxybutyrate Composition for Controlled Ketosis Induction

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Transitioning into and maintaining a ketogenic state is challenging due to the difficulty of depleting glucose stores, accompanied by hypoglycemia, electrolyte imbalance, and discomfort, and existing compositions often omit or discourage the use of S-beta-hydroxybutyrate, which may be ineffective or harmful.

Innovation Solution

Administering S-beta-hydroxybutyrate in enantiomerically pure or enriched form, combined with R-beta-hydroxybutyrate, to induce and maintain a state of ketosis, using non-racemic mixtures with a higher proportion of S-beta-hydroxybutyrate to modulate metabolic effects and reduce electrolyte imbalance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional ketogenic diets are used to deplete glucose stores and induce ketosis, then ketone body levels increase, but hypoglycemia, electrolyte imbalance, and discomfort occur

Engineering Contradiction:

Improveketone body levelsVSAvoidhypoglycemia and electrolyte imbalance

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent introduces S-beta-hydroxybutyrate as an intermediary substance that mediates the transition to ketosis. Rather than allowing natural ketosis induction through glucose depletion (which causes harmful effects), S-BHB directly supplies ketone bodies to the system, acting as a bridge that achieves the desired metabolic state without the harmful transitional effects

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent applies preliminary action by administering S-beta-hydroxybutyrate before the harmful effects of natural ketosis induction can occur. This pre-supplementation approach establishes ketone body levels in advance, preventing the hypoglycemia and electrolyte imbalance that would otherwise result from glucose store depletion

Inventive Principle:

Principle #10Preliminary action

2Reliability

If S-beta-hydroxybutyrate is omitted or discouraged in ketogenic compositions, then R-beta-hydroxybutyrate can be used, but the compositions may be ineffective or harmful

Engineering Contradiction:

Improveeffectiveness of ketogenic compositionVSAvoidineffectiveness or harm from omitting S-enantiomer

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies asymmetry by emphasizing the importance of the S-enantiomer of beta-hydroxybutyrate over the R-enantiomer. Rather than treating both enantiomers equally or omitting S-BHB, the invention creates an asymmetric composition enriched with the S-enantiomer, recognizing that the two enantiomers have different biological activities and that S-BHB is particularly effective for inducing flow states

Inventive Principle:

Principle #4Asymmetry

Solution Approach 2:

The patent applies local quality by specifying that the ketogenic composition should be enriched with S-beta-hydroxy butyrate rather than using a racemic mixture. This localized enhancement of the S-enantiomer content creates a composition with optimized properties for inducing flow, rather than relying on general ketosis induction from either enantiomer

Inventive Principle:

Principle #3Local quality

3Quantity of substance

If natural ketosis induction methods are used, then glucose stores are depleted, but the process is physically and emotionally demanding and challenging

Engineering Contradiction:

Improveglucose store depletionVSAvoiddifficulty of transitioning into ketosis

Core Design Contradiction:

Quantity of substanceVSEase of operation

Solution Approach 1:

The patent replaces the mechanical process of glucose depletion (which requires fasting, exercise, and dietary restriction) with a chemical/biochemical approach. By administering S-beta-hydroxy butyrate, the invention substitutes the mechanical effort of depleting glucose stores with a direct biochemical intervention that achieves ketosis without the physical demands

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Data Source

PatentUS12514841B2Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow

Publication Date: 2026.01.06 AXCESS GLOBAL SCIENCES LLC

AI summary

Compositions for inducing and maintaining a state of flow in a subject include optically pure S-beta-hydroxybutyrate or non-racemic mixtures enriched with the S-enantiomer. The S-beta-hydroxybutyrate enantiomer modulates the effect of ketone bodies in the subject and controls the rate at which ketosis is achieved. Beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. Beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and can provide one or more electrolytes. Compositions for controlling ketone body level in a subject may contain a dietetically or pharmaceutically acceptable carrier and optically pure S-beta-hydroxybutyrate or non-racemic mixture enriched with S-beta-hydroxybutyrate, wherein the compositions contain from about 50.5% to 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and from about 49.5% to 0% by enantiomeric equivalents of R-beta-hydroxybutyrate.