S-Nitroso Collagen Scaffold for Chronic Wound Healing
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current wound healing technologies, particularly for diabetic foot ulcers, face challenges in effectively delivering nitric oxide (NO) to stimulate blood flow and combat microbial infections, while also addressing the chronic inflammation and elevated matrix metalloproteinases (MMPs) that hinder wound healing.
Innovation Solution
The development of a S-nitroso collagen scaffold that incorporates S-nitroso groups to deliver exogenous NO in a controlled and localized manner, utilizing collagen derived from mammalian or marine sources, such as jellyfish, to enhance wound healing by promoting blood flow and reducing microbial infections.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional collagen dressings are used, then wound healing is supported, but nitric oxide delivery is insufficient to effectively stimulate blood flow and combat microbial infections
Solution Approach 1:
The patent modifies collagen molecules by introducing S-nitroso groups through chemical conjugation, changing the chemical parameters of collagen to enable controlled NO release. This transforms conventional collagen into S-nitroso collagen that can deliver nitric oxide to stimulate blood flow and combat infections in chronic wounds
Solution Approach 2:
The patent creates a composite material system combining collagen with nitric oxide delivery capabilities through S-nitroso modification. This composite approach integrates the structural benefits of collagen with the therapeutic effects of nitric oxide, achieving both wound healing support and enhanced NO delivery
2Quantity of substance
If S-nitroso groups are introduced into collagen, then nitric oxide delivery is enhanced, but the manufacturing process complexity increases
Solution Approach 1:
The patent uses an intermediary coupling mechanism to attach nitric oxide or nitric oxide precursors to collagen molecules. This intermediary approach enables controlled NO release while maintaining a manageable manufacturing process, avoiding direct complex synthesis while achieving the desired therapeutic effect
3Reliability
If collagen is modified to release nitric oxide, then blood flow stimulation and antimicrobial activity improve, but control over release kinetics becomes more difficult
Solution Approach 1:
The patent introduces dynamic release characteristics to the collagen system, where nitric oxide is released in a controlled manner in response to wound conditions. The S-nitroso groups provide a mechanism for regulated NO release that can adapt to the dynamic environment of chronic wounds, balancing therapeutic effect with controllable release kinetics
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The S-nitroso collagen scaffold effectively releases NO to stimulate blood flow, reduce microbial infections, and promote wound healing by modulating leukocyte migration and increasing collagen deposition, thereby addressing the limitations of existing wound healing technologies.
Implementation Method 1
modified collagen which can be formulated with one or both of other collagen species and other polymers to fabricate films, membranes, hydrogels and other constructs capable of producing stable gel or membrane based scaffolds for application as a wound healing medical device
Implementation Method 2
The development of a S-nitroso collagen scaffold that incorporates S-nitroso groups to deliver exogenous NO in a controlled and localized manner
Implementation Method 3
promote wound healing by modulating leukocyte migration and increasing collagen deposition
Data Source
AI summary
The present invention provides a method of producing a modified collagen, including the steps of: providing a collagen comprising a S—S bond; introducing a —SH group in said collagen comprising a S—S bond by reduction of the S—S bond to provide a collagen thiol comprising a —SH group; and nitrosating the —SH group of the collagen thiol to provide a modified collagen, said modified collagen comprising S-nitroso groups.